TY - JOUR
T1 - Introducing the hypothome
T2 - a way to integrate predicted proteins in interactomes
AU - Madsen, Claus Desler
AU - Zambach, Sine
AU - Suravajhala, Prashanth
AU - Rasmussen, Lene Juel
PY - 2014
Y1 - 2014
N2 - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome.
AB - An interactome is defined as a network of protein-protein interactions built from experimentally verified interactions. Basic science as well as application-based research of potential new drugs can be promoted by including proteins that are only predicted into interactomes. The disadvantage of doing so is the risk of devaluing the definition of interactomes. By adding proteins that have only been predicted, an interactome can no longer be classified as experimentally verified and the integrity of the interactome will be endured. Therefore, we propose the term 'hypothome' (collection of hypothetical interactions of predicted proteins). The purpose of such a term is to provide a denotation to the interactome concept allowing the interaction of predicted proteins without devaluing the integrity of the interactome. We define a rule-set for a hypothome and have integrated the predicted protein interaction partners to the hypothetical protein. EAW74251 is an example for the usage of a hypothome.
U2 - 10.1504/ijbra.2014.065247
DO - 10.1504/ijbra.2014.065247
M3 - Journal article
C2 - 25335568
SN - 1744-5485
VL - 10
SP - 647
EP - 652
JO - International Journal of Bioinformatics Research and Applications
JF - International Journal of Bioinformatics Research and Applications
IS - 6
ER -