Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin

Nazikussabah Binti Zaharudin, Dan Stærk, Lars Ove Dragsted

37 Citationer (Scopus)

Abstract

A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography-mass spectrometry (HPLC-HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.

OriginalsprogEngelsk
TidsskriftFood Chemistry
Vol/bind270
Sider (fra-til)481-486
Antal sider6
ISSN0308-8146
DOI
StatusUdgivet - 1 jan. 2019

Emneord

  • Det Natur- og Biovidenskabelige Fakultet

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