Influence of preparation pathway on the glass forming ability

Lasse Ingerslev Blaabjerg; Eleanor Lindenberg; Thomas Rades; Holger Grohganz; Korbinian Löbmann

doi:10.1016/j.ijpharm.2017.02.042

Influence of preparation pathway on the glass forming ability

Lasse Ingerslev Blaabjerg, Eleanor Lindenberg, Thomas Rades, Holger Grohganz, Korbinian Löbmann

12 Citationer (Scopus)

Abstract

The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.

Originalsprog	Engelsk
Tidsskrift	International Journal of Pharmaceutics
Vol/bind	521
Udgave nummer	1-2
Sider (fra-til)	232-238
ISSN	0378-5173
DOI	https://doi.org/10.1016/j.ijpharm.2017.02.042
Status	Udgivet - 15 apr. 2017

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10.1016/j.ijpharm.2017.02.042

Citationsformater

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AU - Blaabjerg, Lasse Ingerslev

AU - Lindenberg, Eleanor

AU - Rades, Thomas

AU - Grohganz, Holger

AU - Löbmann, Korbinian

PY - 2017/4/15

Y1 - 2017/4/15

N2 - The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.

AB - The glass forming ability (GFA), i.e. the ease of amorphization of drugs, is mostly investigated using the critical cooling rate upon melt quenching to generate an amorphous product via the thermodynamic pathway. However, amorphous materials can also be prepared via the kinetic pathway by milling. In this case, the time required to generate an amorphous product is called the minimal milling time. This study investigates the correlation of the GFA between these two pathways. Eighteen compounds were chosen and their GFA was investigated by determining the critical cooling rate and the minimal milling time. It was observed that drugs, which turned amorphous upon cooling from the melt at slow cooling rates also had a low minimal milling time and vice versa. It was found that the GFA of the studied set of drugs was inherent and independent of the preparation method. It can be concluded that a drug with low critical cooling rate will also have a low minimal milling time and is thus a good glass former.

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JO - International Journal of Pharmaceutics

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Influence of preparation pathway on the glass forming ability

Abstract

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