@article{c3734c500fc911de8478000ea68e967b,
title = "Induction of acyl-CoA-binding protein and its mRNA in 3T3-L1 cells by insulin during preadipocyte-to-adipocyte differentiation",
abstract = "The induction of acyl-CoA-binding protein (ACBP) and ACBP mRNA was investigated in 3T3-L1 cells during growth and insulin-induced differentiation. The level of ACBP relative to both total soluble protein and DNA increased during insulin-stimulated conversion of 3T3-L1 cells from preadipocytes into fully developed adipocytes. So did the total rate of lipogenesis, as measured by incorporation of [1-14C]acetate. A similar increase in ACBP mRNA relative to total RNA was observed. These results therefore suggest that ACBP plays a specific role in the lipogenic process. However, this role might be indirect, as the increase in lipogenesis preceded the increase in ACBP. The significance of this finding is discussed.",
author = "Hansen, {H O} and Andreasen, {P H} and S Mandrup and K Kristiansen and J Knudsen",
note = "Keywords: Acetates; Adipose Tissue; Animals; Carrier Proteins; Cell Differentiation; Cell Line; Cloning, Molecular; Dexamethasone; Diazepam Binding Inhibitor; Gene Library; Kinetics; Lipids; Liver; Mice; RNA, Messenger; Rats; Rats, Inbred Strains; Time Factors",
year = "1991",
language = "English",
volume = "277 ( Pt 2)",
pages = "341--4",
journal = "Biochemical Journal",
issn = "0264-6021",
publisher = "Portland Press Ltd.",
}