Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Stéphane Duigou; Kristine G. Knudsen; Ole Skovgaard; Elizabeth S Egan; Anders Løbner-Olesen; Matthew K Waldor

doi:10.1128/JB.00565-06

Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Stéphane Duigou, Kristine G. Knudsen, Ole Skovgaard, Elizabeth S Egan, Anders Løbner-Olesen, Matthew K Waldor

60 Citationer (Scopus)

Abstract

Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

Originalsprog	Engelsk
Tidsskrift	Journal of Bacteriology
Vol/bind	188
Udgave nummer	17
Sider (fra-til)	6419-6424
Antal sider	6
ISSN	0021-9193
DOI	https://doi.org/10.1128/JB.00565-06
Status	Udgivet - 2006
Udgivet eksternt	Ja

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10.1128/JB.00565-06

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@article{9f6556ab3e8140b7b326ed479f3791ba,

title = "Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB",

abstract = "Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.",

keywords = "Bacterial Proteins/physiology, Chromosomes, Bacterial/genetics, DNA Replication, DNA-Binding Proteins/physiology, Vibrio cholerae/genetics",

author = "St{\'e}phane Duigou and Knudsen, {Kristine G.} and Ole Skovgaard and Egan, {Elizabeth S} and Anders L{\o}bner-Olesen and Waldor, {Matthew K}",

year = "2006",

doi = "10.1128/JB.00565-06",

language = "English",

volume = "188",

pages = "6419--6424",

journal = "Journal of Bacteriology",

issn = "0021-9193",

publisher = "American Society for Microbiology",

number = "17",

}

TY - JOUR

T1 - Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

AU - Duigou, Stéphane

AU - Knudsen, Kristine G.

AU - Skovgaard, Ole

AU - Egan, Elizabeth S

AU - Løbner-Olesen, Anders

AU - Waldor, Matthew K

PY - 2006

Y1 - 2006

N2 - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

AB - Although the two Vibrio cholerae chromosomes initiate replication in a coordinated fashion, we show here that each chromosome appears to have a specific replication initiator. DnaA overproduction promoted overinitiation of chromosome I and not chromosome II. In contrast, overproduction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overinitiation of chromosome II and not chromosome I.

KW - Bacterial Proteins/physiology

KW - Chromosomes, Bacterial/genetics

KW - DNA Replication

KW - DNA-Binding Proteins/physiology

KW - Vibrio cholerae/genetics

U2 - 10.1128/JB.00565-06

DO - 10.1128/JB.00565-06

M3 - Journal article

C2 - 16923911

SN - 0021-9193

VL - 188

SP - 6419

EP - 6424

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 17

ER -

Independent control of replication initiation of the two Vibrio cholerae chromosomes by DnaA and RctB

Abstract

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