Improvement of dissolution rate of indomethacin by inkjet printing.

TY - JOUR

T1 - Improvement of dissolution rate of indomethacin by inkjet printing.

AU - Wickström, Henrika

AU - Palo, Mirja

AU - Rijckaert, Karen

AU - Kolakovic, Ruzica

AU - Nyman, Johan O

AU - Määttänen, Anni

AU - Ihalainen, Petri

AU - Peltonen, Jouko

AU - Genina, Natalja

AU - de Beer, Thomas

AU - Löbmann, Korbinian

AU - Rades, Thomas

AU - Sandler, Niklas

PY - 2015/7/30

Y1 - 2015/7/30

N2 - The aim of this study was to prepare printable inks of the poorly water soluble drug indomethacin (IMC), fabricate printed systems with flexible doses and investigate the effect of ink excipients on the printability, dissolution rate and the solid state properties of the drug. A piezoelectric inkjet printer was used to print 1×1cm2 squares onto a paper substrate and an impermeable transparency film. l-arginine (ARG) and polyvinylpyrrolidone (PVP) were used as additional formulation excipients. Accurately dosed samples were generated as a result of the ink and droplet formation optimization. Increased dissolution rate was obtained for all formulations. The formulation with IMC and ARG printed on transparency film resulted in a co-amorphous system. The solid state characteristics of the printed drug on porous paper substrates were not possible to determine due to strong interference from the spectra of the carrier substrate. Yet, the samples retained their yellow color after 6months of storage at room temperature and after drying at elevated temperature in a vacuum oven. This suggests that the samples remained either in a dissolved or an amorphous form. Based on the results from this study a formulation guidance for inkjet printing of poorly soluble drugs is also proposed.

AB - The aim of this study was to prepare printable inks of the poorly water soluble drug indomethacin (IMC), fabricate printed systems with flexible doses and investigate the effect of ink excipients on the printability, dissolution rate and the solid state properties of the drug. A piezoelectric inkjet printer was used to print 1×1cm2 squares onto a paper substrate and an impermeable transparency film. l-arginine (ARG) and polyvinylpyrrolidone (PVP) were used as additional formulation excipients. Accurately dosed samples were generated as a result of the ink and droplet formation optimization. Increased dissolution rate was obtained for all formulations. The formulation with IMC and ARG printed on transparency film resulted in a co-amorphous system. The solid state characteristics of the printed drug on porous paper substrates were not possible to determine due to strong interference from the spectra of the carrier substrate. Yet, the samples retained their yellow color after 6months of storage at room temperature and after drying at elevated temperature in a vacuum oven. This suggests that the samples remained either in a dissolved or an amorphous form. Based on the results from this study a formulation guidance for inkjet printing of poorly soluble drugs is also proposed.

KW - Co-amorphous system

KW - Indomethacin

KW - Ink formulation

KW - Inkjet printing

KW - Personalized medicine

U2 - 10.1016/j.ejps.2015.03.009

DO - 10.1016/j.ejps.2015.03.009

M3 - Journal article

C2 - 25817804

SN - 0928-0987

VL - 75

SP - 91

EP - 100

JO - Norvegica Pharmaceutica Acta

JF - Norvegica Pharmaceutica Acta

ER -