Impact of pre-admission depression on mortality following myocardial infarction

TY - JOUR

T1 - Impact of pre-admission depression on mortality following myocardial infarction

AU - Sundbøll, Jens

AU - Schmidt, Morten

AU - Adelborg, Kasper

AU - Pedersen, Lars

AU - Bøtker, Hans Erik

AU - Videbech, Poul

AU - Sørensen, Henrik Toft

N1 - © The Royal College of Psychiatrists 2017.

PY - 2017/5

Y1 - 2017/5

N2 - BackgroundThe prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.

AB - BackgroundThe prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Denmark/epidemiology

KW - Depressive Disorder/complications

KW - Female

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/mortality

KW - Prognosis

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1192/bjp.bp.116.194605

DO - 10.1192/bjp.bp.116.194605

M3 - Journal article

C2 - 28254961

SN - 0007-1250

VL - 210

SP - 356

EP - 361

JO - The British journal of psychiatry : the journal of mental science

JF - The British journal of psychiatry : the journal of mental science

IS - 5

ER -