Abstract
BackgroundThe prognostic impact of previous depression on myocardial infarction survival remains poorly understood.AimsTo examine the association between depression and all-cause mortality following myocardial infarction.MethodUsing Danish medical registries, we conducted a nationwide population-based cohort study. We included all patients with first-time myocardial infarction (1995-2014) and identified previous depression as either a depression diagnosis or use of antidepressants. We used Cox regression to compute adjusted mortality rate ratios (aMRRs) with 95% confidence intervals.ResultsWe identified 170 771 patients with first-time myocardial infarction. Patients with myocardial infarction and a previous depression diagnosis had higher 19-year mortality risks (87% v. 78%). The overall aMRR was 1.11 (95% CI 1.07-1.15) increasing to 1.22 (95% CI 1.17-1.27) when including use of antidepressants in the depression definition.ConclusionsA history of depression was associated with a moderately increased all-cause mortality following myocardial infarction.
| Original language | English |
|---|---|
| Journal | The British journal of psychiatry : the journal of mental science |
| Volume | 210 |
| Issue number | 5 |
| Pages (from-to) | 356-361 |
| ISSN | 0007-1250 |
| DOIs | |
| Publication status | Published - May 2017 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Denmark/epidemiology
- Depressive Disorder/complications
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Myocardial Infarction/mortality
- Prognosis
- Prospective Studies
- Risk Factors