TY - JOUR
T1 - IgM, FcµRs, and malarial immune evasion
AU - Czajkowsky, Daniel M
AU - Salanti, Ali
AU - Ditlev, Sisse B
AU - Shao, Zhifeng
AU - Ghumra, Ashfaq
AU - Rowe, J Alexandra
AU - Pleass, Richard J
PY - 2010/5/1
Y1 - 2010/5/1
N2 - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.
AB - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.
U2 - 10.4049/jimmunol.1000203
DO - 10.4049/jimmunol.1000203
M3 - Journal article
C2 - 20410497
SN - 0022-1767
VL - 184
SP - 4597
EP - 4603
JO - Journal of Immunology
JF - Journal of Immunology
IS - 9
ER -
