IgM, FcµRs, and malarial immune evasion

Daniel M Czajkowsky; Ali Salanti; Sisse B Ditlev; Zhifeng Shao; Ashfaq Ghumra; J Alexandra Rowe; Richard J Pleass

doi:10.4049/jimmunol.1000203

IgM, FcµRs, and malarial immune evasion

Daniel M Czajkowsky, Ali Salanti, Sisse B Ditlev, Zhifeng Shao, Ashfaq Ghumra, J Alexandra Rowe, Richard J Pleass

26 Citations (Scopus)

Abstract

IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

Original language	English
Journal	Journal of Immunology
Volume	184
Issue number	9
Pages (from-to)	4597-603
Number of pages	6
ISSN	0022-1767
DOIs	https://doi.org/10.4049/jimmunol.1000203
Publication status	Published - 1 May 2010

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title = "IgM, FcµRs, and malarial immune evasion",

abstract = "IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.",

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T1 - IgM, FcµRs, and malarial immune evasion

AU - Czajkowsky, Daniel M

AU - Salanti, Ali

AU - Ditlev, Sisse B

AU - Shao, Zhifeng

AU - Ghumra, Ashfaq

AU - Rowe, J Alexandra

AU - Pleass, Richard J

PY - 2010/5/1

Y1 - 2010/5/1

N2 - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

AB - IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered FcμR localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.

U2 - 10.4049/jimmunol.1000203

DO - 10.4049/jimmunol.1000203

M3 - Journal article

C2 - 20410497

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JO - Journal of Immunology

JF - Journal of Immunology

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IgM, FcµRs, and malarial immune evasion

Abstract

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