Identification of the ClpX Regulon in Staphylococcus aureus

Lotte Jelsbak; Line Elnif Thomsen; Hanne Ingmer; Stefanie Donat; Knut Ohlsen; Dorte Frees

Identification of the ClpX Regulon in Staphylococcus aureus

Lotte Jelsbak, Line Elnif Thomsen, Hanne Ingmer, Stefanie Donat, Knut Ohlsen, Dorte Frees

Abstract

Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.

Originalsprog	Engelsk
Publikationsdato	2006
Antal sider	1
Status	Udgivet - 2006
Begivenhed	ASM General Meeting - Orlando, Florida, USA Varighed: 21 maj 2006 → 25 maj 2006 Konferencens nummer: 106

Konference

Konference	ASM General Meeting
Nummer	106
Land/Område	USA
By	Orlando, Florida
Periode	21/05/2006 → 25/05/2006

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Identification of the ClpX Regulon in Staphylococcus aureusForlagets udgivne version, 1,1 MB

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title = "Identification of the ClpX Regulon in Staphylococcus aureus",

abstract = "Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.",

author = "Lotte Jelsbak and Thomsen, {Line Elnif} and Hanne Ingmer and Stefanie Donat and Knut Ohlsen and Dorte Frees",

year = "2006",

language = "English",

note = "ASM General Meeting ; Conference date: 21-05-2006 Through 25-05-2006",

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TY - CONF

T1 - Identification of the ClpX Regulon in Staphylococcus aureus

AU - Jelsbak, Lotte

AU - Thomsen, Line Elnif

AU - Ingmer, Hanne

AU - Donat, Stefanie

AU - Ohlsen, Knut

AU - Frees, Dorte

N1 - Conference code: 106

PY - 2006

Y1 - 2006

N2 - Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.

AB - Staphyloccous aureus is a major human pathogen capable of causing a wide spectrum of infections ranging from superficial wound infections to life-threatening endocarditis and toxic shock syndrome. Essential for S. aureus virulence is a large number of cell-surface-associated proteins and secreted proteins. Results from our group have shown that the ClpXP proteolytic complex and the ClpX chaperone play central roles in regulating expression of many of these factors (2;3). By using DNA microarrays to compare transcription of strain 8325-4 (wt) and the isogenic ¿clpX strain during the transition phase we show here that almost 400 genes (15%) are influenced by the clpX deletion. Furthermore, ClpX not only regulates many virulence factors, but rather serves as a global regulator of central functions for S. aureus lifestyle and pathogenicity.

M3 - Poster

T2 - ASM General Meeting

Y2 - 21 May 2006 through 25 May 2006

ER -

Identification of the ClpX Regulon in Staphylococcus aureus

Abstract

Konference

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