HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity

Kenneth Thermann Kongstad; Johan Andersen-Ranberg; Björn Robert Hamberger; Dan Stærk

HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity

Kenneth Thermann Kongstad, Johan Andersen-Ranberg, Björn Robert Hamberger, Dan Stærk

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Abstract

In this work, the analytical technique, HPLC-HRMS-SPE-NMR was used for the first time in combination with combinatorial biosynthetic investigations in N. benthamiana. This efficient setup allowed for identification of several diterpene synthase (diTPS) combinations responsible for stereospecific biosynthesis of high-value natural products and stereoisomers.

Originalsprog	Engelsk
Publikationsdato	2016
Antal sider	1
Status	Udgivet - 2016
Begivenhed	37th Danish NMR Meeting - Hotel Fuglsøcentret, Knebel, Danmark Varighed: 18 jan. 2016 → 19 jan. 2016

Konference

Konference	37th Danish NMR Meeting
Lokation	Hotel Fuglsøcentret
Land/Område	Danmark
By	Knebel
Periode	18/01/2016 → 19/01/2016

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NMRMeetingPoster2016_KennethKongstad

Citationsformater

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title = "HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity",

abstract = "In this work, the analytical technique, HPLC-HRMS-SPE-NMR was used for the first time in combination with combinatorial biosynthetic investigations in N. benthamiana. This efficient setup allowed for identification of several diterpene synthase (diTPS) combinations responsible for stereospecific biosynthesis of high-value natural products and stereoisomers.",

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T1 - HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity

AU - Kongstad, Kenneth Thermann

AU - Andersen-Ranberg, Johan

AU - Hamberger, Björn Robert

AU - Stærk, Dan

PY - 2016

Y1 - 2016

N2 - In this work, the analytical technique, HPLC-HRMS-SPE-NMR was used for the first time in combination with combinatorial biosynthetic investigations in N. benthamiana. This efficient setup allowed for identification of several diterpene synthase (diTPS) combinations responsible for stereospecific biosynthesis of high-value natural products and stereoisomers.

AB - In this work, the analytical technique, HPLC-HRMS-SPE-NMR was used for the first time in combination with combinatorial biosynthetic investigations in N. benthamiana. This efficient setup allowed for identification of several diterpene synthase (diTPS) combinations responsible for stereospecific biosynthesis of high-value natural products and stereoisomers.

M3 - Poster

T2 - 37th Danish NMR Meeting

Y2 - 18 January 2016 through 19 January 2016

ER -

HPLC-SPE-NMR for combinatorial biosynthetic investigations – expanding the landscape of diterpene structural diversity

Abstract

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