Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals

Simona Denise  Frederiksen; Peter Karlskov-Mortensen; Sameer D. Pant; Maryse Guerin; Philippe Lesnik; Claus B. Jørgensen; Susanna Cirera Salicio; Camilla Vibeke Sichlau Bruun; Thomas Mark; Merete Fredholm

doi:10.1371/journal.pone.0178828

Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals

Simona Denise Frederiksen, Peter Karlskov-Mortensen, Sameer D. Pant, Maryse Guerin, Philippe Lesnik, Claus B. Jørgensen, Susanna Cirera Salicio, Camilla Vibeke Sichlau Bruun, Thomas Mark, Merete Fredholm

3 Citationer (Scopus)

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Abstract

We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.

Originalsprog	Engelsk
Artikelnummer	e0178828
Tidsskrift	PLoS ONE
Vol/bind	12
Udgave nummer	6
Antal sider	13
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0178828
Status	Udgivet - 2017

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10.1371/journal.pone.0178828Licens: CC BY

Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individualsForlagets udgivne version, 5,37 MBLicens: CC BY

Citationsformater

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title = "Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals",

abstract = "We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.",

author = "Frederiksen, {Simona Denise} and Peter Karlskov-Mortensen and Pant, {Sameer D.} and Maryse Guerin and Philippe Lesnik and J{\o}rgensen, {Claus B.} and {Cirera Salicio}, Susanna and Bruun, {Camilla Vibeke Sichlau} and Thomas Mark and Merete Fredholm",

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T1 - Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals

AU - Frederiksen, Simona Denise

AU - Karlskov-Mortensen, Peter

AU - Pant, Sameer D.

AU - Guerin, Maryse

AU - Lesnik, Philippe

AU - Jørgensen, Claus B.

AU - Cirera Salicio, Susanna

AU - Bruun, Camilla Vibeke Sichlau

AU - Mark, Thomas

AU - Fredholm, Merete

PY - 2017

Y1 - 2017

N2 - We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.

AB - We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.

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DO - 10.1371/journal.pone.0178828

M3 - Journal article

C2 - 28570654

AN - SCOPUS:85020019766

SN - 1932-6203

VL - 12

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 6

M1 - e0178828

ER -

Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals

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