TY - JOUR
T1 - Haplotypes on pig chromosome 3 distinguish metabolically healthy from unhealthy obese individuals
AU - Frederiksen, Simona Denise
AU - Karlskov-Mortensen, Peter
AU - Pant, Sameer D.
AU - Guerin, Maryse
AU - Lesnik, Philippe
AU - Jørgensen, Claus B.
AU - Cirera Salicio, Susanna
AU - Bruun, Camilla Vibeke Sichlau
AU - Mark, Thomas
AU - Fredholm, Merete
PY - 2017
Y1 - 2017
N2 - We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.
AB - We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Gottingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on blood lipid levels. The most significantly associated single nucleotide polymorphisms (SNPs) were used for linkage disequilibrium (LD) and haplotype analyses. Three separate haploblocks which influence the ratio between high density lipoprotein cholesterol and total cholesterol (HDL-C/CT), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels respectively were identified on Sus Scrofa chromosome 3 (SSC3). Large additive genetic effects were found for the HDL-C/CT and LDL-C haplotypes. Haplotypes segregating from Gottingen Minipigs were shown to impose a positive effect on blood lipid levels. Thus, the genetic profile of the Gottingen Minipig breed seems to support a phenotype comparable to the metabolic healthy obese (MHO) phenotype in humans.
U2 - 10.1371/journal.pone.0178828
DO - 10.1371/journal.pone.0178828
M3 - Journal article
C2 - 28570654
AN - SCOPUS:85020019766
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0178828
ER -
