Abstract
PURPOSE OF REVIEW: This article highlights recent advances in our understanding of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) physiology and their various sites of action beyond the incretin effect. RECENT FINDINGS: Both GLP-1 and GIP stimulate insulin secretion in a glucose-dependent manner and are thus classified as incretins. Beyond glucose-dependent insulin secretion, the peptides have common actions on islet β cells, leading β-cell proliferation and resistance to apoptosis. However, the action of GLP-1 and GIP is not limited to the islet cells; they have regulatory functions in many organs. Recent evidence has suggested that GLP-1 has important beneficial effects in the cardiovascular system and central nervous system. GIP may play a role in promoting energy storage in humans, enhances bone formation via stimulation of osteoblast proliferation and inhibition of apoptosis and may play a role in central nervous system function. SUMMARY: These new findings suggest further application of these hormones for the treatment of conditions such as cardiovascular disease and obesity.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Current Opinion in Endocrinology, Diabetes and Obesity |
| Vol/bind | 17 |
| Udgave nummer | 1 |
| Sider (fra-til) | 57-62 |
| Antal sider | 6 |
| ISSN | 1752-296X |
| Status | Udgivet - 1 feb. 2010 |
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