Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

TY - JOUR

T1 - Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

AU - Nielsen, Peter E

PY - 2010

Y1 - 2010

N2 - Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as gene targeting agents for drug discovery approaches. An overview with emphasis on recent progress on RNA "interference" (antisense), targeting of duplex DNA and gene targeted repair and transcription interference using PNA, as well as on PNA delivery and potential PNA anti-infectives is given.

AB - Peptide nucleic acids (PNA) are artificial structural mimics of nucleic acids capable of sequence specific hybridization to both RNA and DNA. Thus they have obvious potential as gene targeting agents for drug discovery approaches. An overview with emphasis on recent progress on RNA "interference" (antisense), targeting of duplex DNA and gene targeted repair and transcription interference using PNA, as well as on PNA delivery and potential PNA anti-infectives is given.

M3 - Journal article

C2 - 20687874

SN - 1381-6128

VL - 16

SP - 3118

EP - 3123

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

IS - 28

ER -