Functions of myosin motors tailored for parasitism

TY - JOUR

T1 - Functions of myosin motors tailored for parasitism

AU - Mueller, Christina

AU - Graindorge, Arnault

AU - Soldati-Favre, Dominique

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Myosin motors are one of the largest protein families in eukaryotes that exhibit divergent cellular functions. Their roles in protozoans, a diverse group of anciently diverged, single celled organisms with many prominent members known to be parasitic and to cause diseases in human and livestock, are largely unknown. In the recent years many different approaches, among them whole genome sequencing, phylogenetic analyses and functional studies have increased our understanding on the distribution, protein architecture and function of unconventional myosin motors in protozoan parasites. In Apicomplexa, myosins turn out to be highly specialized and to exhibit unique functions tailored to accommodate the lifestyle of these parasites.

AB - Myosin motors are one of the largest protein families in eukaryotes that exhibit divergent cellular functions. Their roles in protozoans, a diverse group of anciently diverged, single celled organisms with many prominent members known to be parasitic and to cause diseases in human and livestock, are largely unknown. In the recent years many different approaches, among them whole genome sequencing, phylogenetic analyses and functional studies have increased our understanding on the distribution, protein architecture and function of unconventional myosin motors in protozoan parasites. In Apicomplexa, myosins turn out to be highly specialized and to exhibit unique functions tailored to accommodate the lifestyle of these parasites.

U2 - 10.1016/j.mib.2017.11.003

DO - 10.1016/j.mib.2017.11.003

M3 - Review

C2 - 29161623

AN - SCOPUS:85034597816

SN - 1369-5274

VL - 40

SP - 113

EP - 122

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

ER -