TY - JOUR
T1 - Functional Modeling of the Shift in Cellular Calcium Dynamics at the Onset of Synchronization in Smooth Muscle Cells
AU - Postnov, D E
AU - Brings Jacobsen, J C
AU - von Holstein-Rathlou, Niels-Henrik
AU - Sosnovtseva, Olga
PY - 2011/10
Y1 - 2011/10
N2 - In the present paper we address the nature of synchronization properties found in populations of mesenteric artery smooth muscle cells. We present a minimal model of the onset of synchronization in the individual smooth muscle cell that is manifested as a transition from calcium waves to whole-cell calcium oscillations. We discuss how different types of ion currents may influence both amplitude and frequency in the regime of whole-cell oscillations. The model may also explain the occurrence of mixed-mode oscillations and chaotic oscillations frequently observed in the experimental system.
AB - In the present paper we address the nature of synchronization properties found in populations of mesenteric artery smooth muscle cells. We present a minimal model of the onset of synchronization in the individual smooth muscle cell that is manifested as a transition from calcium waves to whole-cell calcium oscillations. We discuss how different types of ion currents may influence both amplitude and frequency in the regime of whole-cell oscillations. The model may also explain the occurrence of mixed-mode oscillations and chaotic oscillations frequently observed in the experimental system.
U2 - 10.1007/s11538-011-9636-6
DO - 10.1007/s11538-011-9636-6
M3 - Journal article
C2 - 21387191
SN - 0092-8240
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
ER -