Functional modeling of neural-glial interaction

TY - JOUR

T1 - Functional modeling of neural-glial interaction

AU - Postnov, D E

AU - Ryazanova, L S

AU - Sosnovtseva, Olga

PY - 2007

Y1 - 2007

N2 - We propose a generalized mathematical model for a small neural-glial ensemble. The model incorporates subunits of the tripartite synapse that includes a presynaptic neuron, the synaptic terminal itself, a postsynaptic neuron, and a glial cell. The glial cell is assumed to be activated via two different pathways: (i) the fast increase of intercellular [K(+)] produced by the spiking activity of the postsynaptic neuron, and (ii) the slow production of a mediator triggered by the synaptic activity. Our model predicts the long-term potentiation of the postsynaptic neuron as well as various [Ca(2+)] transients in response to the activation of different pathways.

AB - We propose a generalized mathematical model for a small neural-glial ensemble. The model incorporates subunits of the tripartite synapse that includes a presynaptic neuron, the synaptic terminal itself, a postsynaptic neuron, and a glial cell. The glial cell is assumed to be activated via two different pathways: (i) the fast increase of intercellular [K(+)] produced by the spiking activity of the postsynaptic neuron, and (ii) the slow production of a mediator triggered by the synaptic activity. Our model predicts the long-term potentiation of the postsynaptic neuron as well as various [Ca(2+)] transients in response to the activation of different pathways.

KW - Long-Term Potentiation

KW - Models, Neurological

KW - Neuroglia

KW - Neurons

KW - Potassium

U2 - 10.1016/j.biosystems.2006.04.012

DO - 10.1016/j.biosystems.2006.04.012

M3 - Journal article

C2 - 17320272

SN - 0303-2647

VL - 89

SP - 84

EP - 91

JO - BioSystems

JF - BioSystems

IS - 1-3

ER -