From powerhouse to perpetrator—mitochondria in health and disease

TY - JOUR

T1 - From powerhouse to perpetrator—mitochondria in health and disease

AU - Fakouri, Nima B.

AU - Hansen, Thomas Lau

AU - Desler, Claus

AU - Anugula, Sharath

AU - Rasmussen, Lene Juel

PY - 2019

Y1 - 2019

N2 - In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.

AB - In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.

KW - Cancer

KW - DNA damage

KW - Mitochondria

KW - NAD

KW - Nucleotide metabolism

U2 - 10.3390/biology8020035

DO - 10.3390/biology8020035

M3 - Review

C2 - 31083572

AN - SCOPUS:85068536365

SN - 2079-7737

VL - 8

JO - Biology

JF - Biology

IS - 2

M1 - 35

ER -