Fish oil as a potential activator of brown and beige fat thermogenesis

TY - JOUR

T1 - Fish oil as a potential activator of brown and beige fat thermogenesis

AU - Lund, Jens

AU - Larsen, Lesli Hingstrup

AU - Lauritzen, Lotte

N1 - CURIS 2018 NEXS 095

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. This mini-review summarizes the observations in rodents, highlights several mechanisms that might explain these observations and discusses the translational potential. Given the available in vivo evidence and the ability of human adipocytes to aquire a beige phenotype in response to eicosapentaenoic acid incubation, future studies should test the hypothesis that fish oil activates thermogenic brown and beige adipose tissue in humans.

AB - Numerous studies have shown that feeding rodents n-3 polyunsaturated fatty acids attenuates adiposity. Moreover, meta-analyses of human dietary intervention studies indicate that fish oil (eicosapentaenoic and docosahexaenoic acid) supplementation might reduce waist circumference. A recent line of research suggests that browning of white adipose depots and activation of uncoupled respiration in brown fat contributes to these effects. This mini-review summarizes the observations in rodents, highlights several mechanisms that might explain these observations and discusses the translational potential. Given the available in vivo evidence and the ability of human adipocytes to aquire a beige phenotype in response to eicosapentaenoic acid incubation, future studies should test the hypothesis that fish oil activates thermogenic brown and beige adipose tissue in humans.

KW - Faculty of Science

KW - Fish oil

KW - Eicosapentaenoic acid (EPA)

KW - Brown adipose tissue

KW - Browning

KW - Beige adipocytes

KW - UCP1

KW - Non-shivering thermogenesis

KW - GPR120

KW - TRPV1

KW - miR-30b

U2 - 10.1080/21623945.2018.1442980

DO - 10.1080/21623945.2018.1442980

M3 - Review

C2 - 29521565

SN - 1550-2082

VL - 7

SP - 88

EP - 95

JO - Adipocytes

JF - Adipocytes

IS - 2

ER -