Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Jannet Svensson; Stefanie Eising; David Michael Hougaard; Henrik Bindesbøl Mortensen; Kristin Skogstrand; Lars Bjarke Simonsen; Bendix Carstensen; Anita Nilsson; Åke Lernmark; Flemming Pociot; Jesper Johannesen; Danish Childhood Diabetes Registry

doi:10.1016/j.humimm.2012.07.337

Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Jannet Svensson, Stefanie Eising, David Michael Hougaard, Henrik Bindesbøl Mortensen, Kristin Skogstrand, Lars Bjarke Simonsen, Bendix Carstensen, Anita Nilsson, Åke Lernmark, Flemming Pociot, Jesper Johannesen, Danish Childhood Diabetes Registry

14 Citationer (Scopus)

Abstract

The cause of the worldwide increase in type 1 diabetes (T1D) is largely unknown. T cells are thought to play a role in disease progression. In contemporary research over the last decade, age- and gender-specific serum levels as well as changes of Th1 and Th2-related cytokines are not well described. From a population-based register of children diagnosed from 1997 to 2005 this study explores eight different cytokines at time of diagnosis. Only TGF-β and IL-18 showed higher levels in patients compared to siblings in an adjusted model (p

Originalsprog	Engelsk
Tidsskrift	Human Immunology
Vol/bind	73
Udgave nummer	11
Sider (fra-til)	1116-26
Antal sider	11
ISSN	0198-8859
DOI	https://doi.org/10.1016/j.humimm.2012.07.337
Status	Udgivet - nov. 2012

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10.1016/j.humimm.2012.07.337

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Svensson, J., Eising, S., Hougaard, D. M., Mortensen, H. B., Skogstrand, K., Simonsen, L. B., Carstensen, B., Nilsson, A., Lernmark, Å., Pociot, F., Johannesen, J., & Danish Childhood Diabetes Registry (2012). Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings. Human Immunology, 73(11), 1116-26. https://doi.org/10.1016/j.humimm.2012.07.337

Svensson, J, Eising, S, Hougaard, DM, Mortensen, HB, Skogstrand, K, Simonsen, LB, Carstensen, B, Nilsson, A, Lernmark, Å, Pociot, F, Johannesen, J & Danish Childhood Diabetes Registry 2012, 'Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings', Human Immunology, bind 73, nr. 11, s. 1116-26. https://doi.org/10.1016/j.humimm.2012.07.337

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abstract = "The cause of the worldwide increase in type 1 diabetes (T1D) is largely unknown. T cells are thought to play a role in disease progression. In contemporary research over the last decade, age- and gender-specific serum levels as well as changes of Th1 and Th2-related cytokines are not well described. From a population-based register of children diagnosed from 1997 to 2005 this study explores eight different cytokines at time of diagnosis. Only TGF-β and IL-18 showed higher levels in patients compared to siblings in an adjusted model (p",

author = "Jannet Svensson and Stefanie Eising and Hougaard, {David Michael} and Mortensen, {Henrik Bindesb{\o}l} and Kristin Skogstrand and Simonsen, {Lars Bjarke} and Bendix Carstensen and Anita Nilsson and {\AA}ke Lernmark and Flemming Pociot and Jesper Johannesen and Mortensen, {Henrik B.}",

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doi = "10.1016/j.humimm.2012.07.337",

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AU - Svensson, Jannet

AU - Eising, Stefanie

AU - Hougaard, David Michael

AU - Mortensen, Henrik Bindesbøl

AU - Skogstrand, Kristin

AU - Simonsen, Lars Bjarke

AU - Carstensen, Bendix

AU - Nilsson, Anita

AU - Lernmark, Åke

AU - Pociot, Flemming

AU - Johannesen, Jesper

AU - Danish Childhood Diabetes Registry

PY - 2012/11

Y1 - 2012/11

N2 - The cause of the worldwide increase in type 1 diabetes (T1D) is largely unknown. T cells are thought to play a role in disease progression. In contemporary research over the last decade, age- and gender-specific serum levels as well as changes of Th1 and Th2-related cytokines are not well described. From a population-based register of children diagnosed from 1997 to 2005 this study explores eight different cytokines at time of diagnosis. Only TGF-β and IL-18 showed higher levels in patients compared to siblings in an adjusted model (p

AB - The cause of the worldwide increase in type 1 diabetes (T1D) is largely unknown. T cells are thought to play a role in disease progression. In contemporary research over the last decade, age- and gender-specific serum levels as well as changes of Th1 and Th2-related cytokines are not well described. From a population-based register of children diagnosed from 1997 to 2005 this study explores eight different cytokines at time of diagnosis. Only TGF-β and IL-18 showed higher levels in patients compared to siblings in an adjusted model (p

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DO - 10.1016/j.humimm.2012.07.337

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JO - Human Immunology

JF - Human Immunology

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ER -

Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Abstract

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