Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Jannet Svensson; Stefanie Eising; David Michael Hougaard; Henrik Bindesbøl Mortensen; Kristin Skogstrand; Lars Bjarke Simonsen; Bendix Carstensen; Anita Nilsson; Åke Lernmark; Flemming Pociot; Jesper Johannesen; Danish Childhood Diabetes Registry

doi:10.1016/j.humimm.2012.07.337

Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Jannet Svensson, Stefanie Eising, David Michael Hougaard, Henrik Bindesbøl Mortensen, Kristin Skogstrand, Lars Bjarke Simonsen, Bendix Carstensen, Anita Nilsson, Åke Lernmark, Flemming Pociot, Jesper Johannesen, Danish Childhood Diabetes Registry

14 Citations (Scopus)

Abstract

The cause of the worldwide increase in type 1 diabetes (T1D) is largely unknown. T cells are thought to play a role in disease progression. In contemporary research over the last decade, age- and gender-specific serum levels as well as changes of Th1 and Th2-related cytokines are not well described. From a population-based register of children diagnosed from 1997 to 2005 this study explores eight different cytokines at time of diagnosis. Only TGF-β and IL-18 showed higher levels in patients compared to siblings in an adjusted model (p

Original language	English
Journal	Human Immunology
Volume	73
Issue number	11
Pages (from-to)	1116-26
Number of pages	11
ISSN	0198-8859
DOIs	https://doi.org/10.1016/j.humimm.2012.07.337
Publication status	Published - Nov 2012

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Svensson, J., Eising, S., Hougaard, D. M., Mortensen, H. B., Skogstrand, K., Simonsen, L. B., Carstensen, B., Nilsson, A., Lernmark, Å., Pociot, F., Johannesen, J., & Danish Childhood Diabetes Registry (2012). Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings. Human Immunology, 73(11), 1116-26. https://doi.org/10.1016/j.humimm.2012.07.337

Svensson, J, Eising, S, Hougaard, DM, Mortensen, HB, Skogstrand, K, Simonsen, LB, Carstensen, B, Nilsson, A, Lernmark, Å, Pociot, F, Johannesen, J & Danish Childhood Diabetes Registry 2012, 'Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings', Human Immunology, vol. 73, no. 11, pp. 1116-26. https://doi.org/10.1016/j.humimm.2012.07.337

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AU - Skogstrand, Kristin

AU - Simonsen, Lars Bjarke

AU - Carstensen, Bendix

AU - Nilsson, Anita

AU - Lernmark, Åke

AU - Pociot, Flemming

AU - Johannesen, Jesper

AU - Danish Childhood Diabetes Registry

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Few differences in cytokines between patients newly diagnosed with type 1 diabetes and their healthy siblings

Abstract

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