Fabrication of a microfluidic cell made of thiol-ene for microarray applications

TY - GEN

T1 - Fabrication of a microfluidic cell made of thiol-ene for microarray applications

AU - Sola, Laura

AU - Gagni, Paola

AU - Jensen, Thomas G.

AU - Zilio, Caterina

AU - Cretich, Marina

AU - Kutter, Jörg P.

AU - Chiari, Marcella

PY - 2014

Y1 - 2014

N2 - We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.

AB - We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.

KW - Antibody oriented immobilization

KW - Coatings

KW - Microarray

KW - Microfluidics

KW - Thiol-ene

UR - http://www.scopus.com/inward/record.url?scp=84941711095&partnerID=8YFLogxK

M3 - Article in proceedings

AN - SCOPUS:84941711095

SP - 1719

EP - 1721

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -