Fabrication of a microfluidic cell made of thiol-ene for microarray applications

Laura Sola; Paola Gagni; Thomas G. Jensen; Caterina Zilio; Marina Cretich; Jörg P. Kutter; Marcella Chiari

Fabrication of a microfluidic cell made of thiol-ene for microarray applications

Laura Sola^*, Paola Gagni, Thomas G. Jensen, Caterina Zilio, Marina Cretich, Jörg P. Kutter, Marcella Chiari

^*Corresponding author af dette arbejde

Abstract

We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.

Originalsprog	Engelsk
Titel	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Antal sider	3
Forlag	Chemical and Biological Microsystems Society
Publikationsdato	2014
Sider	1719-1721
ISBN (Elektronisk)	9780979806476
Status	Udgivet - 2014
Begivenhed	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, USA Varighed: 26 okt. 2014 → 30 okt. 2014

Konference

Konference	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Land/Område	USA
By	San Antonio
Periode	26/10/2014 → 30/10/2014
Sponsor	Analytical Chemistry, CBMS, Indiana University (IU), Institute of Microchemical Technology (IMT), LPKF Laser and Electronics

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Citationsformater

Fabrication of a microfluidic cell made of thiol-ene for microarray applications. / Sola, Laura; Gagni, Paola; Jensen, Thomas G. et al.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. s. 1719-1721.

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › peer review

Sola, L, Gagni, P, Jensen, TG, Zilio, C, Cretich, M, Kutter, JP & Chiari, M 2014, Fabrication of a microfluidic cell made of thiol-ene for microarray applications. i 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, s. 1719-1721, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, USA, 26/10/2014.

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title = "Fabrication of a microfluidic cell made of thiol-ene for microarray applications",

abstract = "We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.",

keywords = "Antibody oriented immobilization, Coatings, Microarray, Microfluidics, Thiol-ene",

author = "Laura Sola and Paola Gagni and Jensen, {Thomas G.} and Caterina Zilio and Marina Cretich and Kutter, {J{\"o}rg P.} and Marcella Chiari",

year = "2014",

language = "English",

pages = "1719--1721",

booktitle = "18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014",

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T1 - Fabrication of a microfluidic cell made of thiol-ene for microarray applications

AU - Sola, Laura

AU - Gagni, Paola

AU - Jensen, Thomas G.

AU - Zilio, Caterina

AU - Cretich, Marina

AU - Kutter, Jörg P.

AU - Chiari, Marcella

PY - 2014

Y1 - 2014

N2 - We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.

AB - We report on the fabrication of a microfluidic cell completely made of thiol-ene for microarray applications. To overcome the issues related to the hydrophobic nature of the thiol-ene material we have also introduced a new polymeric coating based of N, N-dimethylacrylamide (DMA) which is able to reduce the material hydrophobicity, to avoid aspecific protein binding and, thanks to the functional monomer propinyl mathacrylate, it is able to bind, in an oriented way, azido modified biomolecules.

KW - Antibody oriented immobilization

KW - Coatings

KW - Microarray

KW - Microfluidics

KW - Thiol-ene

UR - http://www.scopus.com/inward/record.url?scp=84941711095&partnerID=8YFLogxK

M3 - Article in proceedings

AN - SCOPUS:84941711095

SP - 1719

EP - 1721

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

Fabrication of a microfluidic cell made of thiol-ene for microarray applications

Abstract

Konference

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