Essential fatty acid composition and correlates in children with severe acute malnutrition

Esther Babirekere-Iriso; Lotte Lauritzen; Charlotte Gylling Mortensen; Maren Johanne Heilskov Rytter; Ezekiel Mupere; Hanifa Namusoke; Kim F. Michaelsen; André Briend; Ken D Stark; Adam H Metherel; Henrik Friis

doi:10.1016/j.clnesp.2015.12.001

Essential fatty acid composition and correlates in children with severe acute malnutrition

Esther Babirekere-Iriso^*, Lotte Lauritzen, Charlotte Gylling Mortensen, Maren Johanne Heilskov Rytter, Ezekiel Mupere, Hanifa Namusoke, Kim F. Michaelsen, André Briend, Ken D Stark, Adam H Metherel, Henrik Friis

^*Corresponding author af dette arbejde

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10 Citationer (Scopus)

Abstract

Background: Severe acute malnutrition (SAM) is a common condition in children living in low-income countries and may be associated with reduced polyunsaturated fatty acids (PUFA) blood levels. The purpose of this study was to describe whole blood fatty acid composition and correlates of PUFA in children admitted with SAM. Methods: We conducted a cross-sectional study among children admitted with SAM at Mulago National Referral Hospital and healthy controls. Whole blood fatty acid composition was measured and correlated with clinical data such as oedema, levels of haemoglobin, C-reactive protein and HIV-infection status. Multiple linear regression analyses were used to identify correlates of PUFA. Results: The relative contribution of saturated fatty acid to the fatty acids in whole blood (FA%) were lower in 108 children with SAM compared to 24 well-nourished controls whereas most monounsaturated fatty acids were higher in children with SAM. Total and all n-6 PUFA including linoleic (18:2n-6, LA) and arachidonic acid (20:4n-6, AA), as well as total n-3 PUFA and docosahexaenoic acid (22:6n-3, DHA) were lower in children with SAM. The n-6:n-3 PUFA ratio was also lower in the children with SAM. Haemoglobin was a positive correlate of AA, n-3 docosapentaenoic acid (22:5n-3, n-3 DPA), DHA, total n-6 long chain (LC) PUFA and total n-3 LCPUFA. HIV infected children had 0.87 (0.47; 1.58) %-points less n-6 LCPUFA and 0.61 (0.03; 1.19) %-points less AA than the un-infected children. Conclusion: Children with SAM presented with lower FA% of LCPUFA. HIV infection and low haemoglobin were also associated with lower FA% of LCPUFA, which may be related to lower numbers of blood cells. Nutrition rehabilitation interventions need to pay more attention to the intake of PUFA.

Originalsprog	Engelsk
Tidsskrift	Clinical Nutrition ESPEN
Vol/bind	11
Sider (fra-til)	e40-e46
Antal sider	7
ISSN	2405-4577
DOI	https://doi.org/10.1016/j.clnesp.2015.12.001
Status	Udgivet - 2016

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@article{2a53fae356474433abfe8ef6fc763c56,

title = "Essential fatty acid composition and correlates in children with severe acute malnutrition",

abstract = "Background: Severe acute malnutrition (SAM) is a common condition in children living in low-income countries and may be associated with reduced polyunsaturated fatty acids (PUFA) blood levels. The purpose of this study was to describe whole blood fatty acid composition and correlates of PUFA in children admitted with SAM. Methods: We conducted a cross-sectional study among children admitted with SAM at Mulago National Referral Hospital and healthy controls. Whole blood fatty acid composition was measured and correlated with clinical data such as oedema, levels of haemoglobin, C-reactive protein and HIV-infection status. Multiple linear regression analyses were used to identify correlates of PUFA. Results: The relative contribution of saturated fatty acid to the fatty acids in whole blood (FA%) were lower in 108 children with SAM compared to 24 well-nourished controls whereas most monounsaturated fatty acids were higher in children with SAM. Total and all n-6 PUFA including linoleic (18:2n-6, LA) and arachidonic acid (20:4n-6, AA), as well as total n-3 PUFA and docosahexaenoic acid (22:6n-3, DHA) were lower in children with SAM. The n-6:n-3 PUFA ratio was also lower in the children with SAM. Haemoglobin was a positive correlate of AA, n-3 docosapentaenoic acid (22:5n-3, n-3 DPA), DHA, total n-6 long chain (LC) PUFA and total n-3 LCPUFA. HIV infected children had 0.87 (0.47; 1.58) %-points less n-6 LCPUFA and 0.61 (0.03; 1.19) %-points less AA than the un-infected children. Conclusion: Children with SAM presented with lower FA% of LCPUFA. HIV infection and low haemoglobin were also associated with lower FA% of LCPUFA, which may be related to lower numbers of blood cells. Nutrition rehabilitation interventions need to pay more attention to the intake of PUFA.",

keywords = "Children, Essential fatty acids, Polyunsaturated fatty acids, Severe acute malnutrition",

author = "Esther Babirekere-Iriso and Lotte Lauritzen and Mortensen, {Charlotte Gylling} and Rytter, {Maren Johanne Heilskov} and Ezekiel Mupere and Hanifa Namusoke and Michaelsen, {Kim F.} and Andr{\'e} Briend and Stark, {Ken D} and Metherel, {Adam H} and Henrik Friis",

note = "CURIS 2016 NEXS 271",

year = "2016",

doi = "10.1016/j.clnesp.2015.12.001",

language = "English",

volume = "11",

pages = "e40--e46",

journal = "Clinical Nutrition ESPEN",

issn = "2405-4577",

publisher = "Elsevier",

}

TY - JOUR

T1 - Essential fatty acid composition and correlates in children with severe acute malnutrition

AU - Babirekere-Iriso, Esther

AU - Lauritzen, Lotte

AU - Mortensen, Charlotte Gylling

AU - Rytter, Maren Johanne Heilskov

AU - Mupere, Ezekiel

AU - Namusoke, Hanifa

AU - Michaelsen, Kim F.

AU - Briend, André

AU - Stark, Ken D

AU - Metherel, Adam H

AU - Friis, Henrik

N1 - CURIS 2016 NEXS 271

PY - 2016

Y1 - 2016

N2 - Background: Severe acute malnutrition (SAM) is a common condition in children living in low-income countries and may be associated with reduced polyunsaturated fatty acids (PUFA) blood levels. The purpose of this study was to describe whole blood fatty acid composition and correlates of PUFA in children admitted with SAM. Methods: We conducted a cross-sectional study among children admitted with SAM at Mulago National Referral Hospital and healthy controls. Whole blood fatty acid composition was measured and correlated with clinical data such as oedema, levels of haemoglobin, C-reactive protein and HIV-infection status. Multiple linear regression analyses were used to identify correlates of PUFA. Results: The relative contribution of saturated fatty acid to the fatty acids in whole blood (FA%) were lower in 108 children with SAM compared to 24 well-nourished controls whereas most monounsaturated fatty acids were higher in children with SAM. Total and all n-6 PUFA including linoleic (18:2n-6, LA) and arachidonic acid (20:4n-6, AA), as well as total n-3 PUFA and docosahexaenoic acid (22:6n-3, DHA) were lower in children with SAM. The n-6:n-3 PUFA ratio was also lower in the children with SAM. Haemoglobin was a positive correlate of AA, n-3 docosapentaenoic acid (22:5n-3, n-3 DPA), DHA, total n-6 long chain (LC) PUFA and total n-3 LCPUFA. HIV infected children had 0.87 (0.47; 1.58) %-points less n-6 LCPUFA and 0.61 (0.03; 1.19) %-points less AA than the un-infected children. Conclusion: Children with SAM presented with lower FA% of LCPUFA. HIV infection and low haemoglobin were also associated with lower FA% of LCPUFA, which may be related to lower numbers of blood cells. Nutrition rehabilitation interventions need to pay more attention to the intake of PUFA.

AB - Background: Severe acute malnutrition (SAM) is a common condition in children living in low-income countries and may be associated with reduced polyunsaturated fatty acids (PUFA) blood levels. The purpose of this study was to describe whole blood fatty acid composition and correlates of PUFA in children admitted with SAM. Methods: We conducted a cross-sectional study among children admitted with SAM at Mulago National Referral Hospital and healthy controls. Whole blood fatty acid composition was measured and correlated with clinical data such as oedema, levels of haemoglobin, C-reactive protein and HIV-infection status. Multiple linear regression analyses were used to identify correlates of PUFA. Results: The relative contribution of saturated fatty acid to the fatty acids in whole blood (FA%) were lower in 108 children with SAM compared to 24 well-nourished controls whereas most monounsaturated fatty acids were higher in children with SAM. Total and all n-6 PUFA including linoleic (18:2n-6, LA) and arachidonic acid (20:4n-6, AA), as well as total n-3 PUFA and docosahexaenoic acid (22:6n-3, DHA) were lower in children with SAM. The n-6:n-3 PUFA ratio was also lower in the children with SAM. Haemoglobin was a positive correlate of AA, n-3 docosapentaenoic acid (22:5n-3, n-3 DPA), DHA, total n-6 long chain (LC) PUFA and total n-3 LCPUFA. HIV infected children had 0.87 (0.47; 1.58) %-points less n-6 LCPUFA and 0.61 (0.03; 1.19) %-points less AA than the un-infected children. Conclusion: Children with SAM presented with lower FA% of LCPUFA. HIV infection and low haemoglobin were also associated with lower FA% of LCPUFA, which may be related to lower numbers of blood cells. Nutrition rehabilitation interventions need to pay more attention to the intake of PUFA.

KW - Children

KW - Essential fatty acids

KW - Polyunsaturated fatty acids

KW - Severe acute malnutrition

UR - http://www.scopus.com/inward/record.url?scp=84961250346&partnerID=8YFLogxK

U2 - 10.1016/j.clnesp.2015.12.001

DO - 10.1016/j.clnesp.2015.12.001

M3 - Journal article

C2 - 28531425

AN - SCOPUS:84961250346

SN - 2405-4577

VL - 11

SP - e40-e46

JO - Clinical Nutrition ESPEN

JF - Clinical Nutrition ESPEN

ER -

Essential fatty acid composition and correlates in children with severe acute malnutrition

Abstract

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