In situ formed suspensions for local sustained action of celecoxib following intra-articular administration

TY - CONF

T1 - In situ formed suspensions for local sustained action of celecoxib following intra-articular administration

AU - Larsen, Susan Weng

AU - Frost, Anna Buus

AU - Østergaard, Jesper

AU - Jacobsen, Stine

AU - Thomsen, Maj Halling

AU - Lindegaard, Casper

AU - Andersen, Pia Haubro

AU - Larsen, Claus Selch

N1 - Conference code: 36

PY - 2009

Y1 - 2009

N2 - In vitro release of celecoxib from in situ formed suspensions intended for intra-articular (IA) delivery has been investigated using a rotating dialysis cell model. The appearance of celecoxib in the acceptor phase after instillation of a concentrated drug solution in PEG 400 into the small aqueous donor compartment was followed by reverse phase HPLC. After an initial fast release a constant flux was observed. Likewise, a similar constant flux was found for a preformed aqueous suspension of the drug. The highly comparable fluxes observed indicate that the solid celecoxib precipitated from the in situ formed suspension exhibited an aqueous solubility similar to that of parent celecoxib used for the preformed aqueous suspension. Results from the in vivo experiments in horses revealed that solid materials  as observed within the synovium of the radiocarpal joint 10 days after IA administration of an in situ formed suspension of celecoxib. In the field of IA drug administration the in situ suspension forming drug delivery principle appears promising for the provision of local prolonged drug action. However, for clinical use the reproducibility of the precipitation step in the biological matrix may still need improvement.

AB - In vitro release of celecoxib from in situ formed suspensions intended for intra-articular (IA) delivery has been investigated using a rotating dialysis cell model. The appearance of celecoxib in the acceptor phase after instillation of a concentrated drug solution in PEG 400 into the small aqueous donor compartment was followed by reverse phase HPLC. After an initial fast release a constant flux was observed. Likewise, a similar constant flux was found for a preformed aqueous suspension of the drug. The highly comparable fluxes observed indicate that the solid celecoxib precipitated from the in situ formed suspension exhibited an aqueous solubility similar to that of parent celecoxib used for the preformed aqueous suspension. Results from the in vivo experiments in horses revealed that solid materials  as observed within the synovium of the radiocarpal joint 10 days after IA administration of an in situ formed suspension of celecoxib. In the field of IA drug administration the in situ suspension forming drug delivery principle appears promising for the provision of local prolonged drug action. However, for clinical use the reproducibility of the precipitation step in the biological matrix may still need improvement.

M3 - Poster

T2 - <strong>36th Annual Meeting &amp; Exposition of the Controlled Release Society</strong>

Y2 - 18 July 2009 through 22 July 2009

ER -