Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids

TY - JOUR

T1 - Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids

AU - Gjelstad, Astrid

AU - Pedersen-Bjergaard, Stig

AU - Seip, Knut Fredrik

PY - 2015/9/1

Y1 - 2015/9/1

N2 - This special report discusses the sample preparation method electromembrane extraction, which was introduced in 2006 as a rapid and selective miniaturized extraction method. The extraction principle is based on isolation of charged analytes extracted from an aqueous sample, across a thin film of organic solvent, and into an aqueous receiver solution. The extraction is promoted by application of an electrical field, causing electrokinetic migration of the charged analytes. The method has shown to perform excellent clean-up and selectivity from complicated aqueous matrices like biological fluids. Technical aspects of electromembrane extraction, important extraction parameters as well as a handful of examples of applications from different biological samples and bioanalytical areas are discussed in the paper.

AB - This special report discusses the sample preparation method electromembrane extraction, which was introduced in 2006 as a rapid and selective miniaturized extraction method. The extraction principle is based on isolation of charged analytes extracted from an aqueous sample, across a thin film of organic solvent, and into an aqueous receiver solution. The extraction is promoted by application of an electrical field, causing electrokinetic migration of the charged analytes. The method has shown to perform excellent clean-up and selectivity from complicated aqueous matrices like biological fluids. Technical aspects of electromembrane extraction, important extraction parameters as well as a handful of examples of applications from different biological samples and bioanalytical areas are discussed in the paper.

U2 - 10.4155/bio.15.150

DO - 10.4155/bio.15.150

M3 - Journal article

C2 - 26340714

SN - 1757-6180

VL - 7

SP - 2203

EP - 2209

JO - Bioanalysis

JF - Bioanalysis

IS - 17

ER -