Effect of postsurgical rehabilitation programmes in patients operated for lung cancer: A systematic review and meta-analysis

TY - JOUR

T1 - Effect of postsurgical rehabilitation programmes in patients operated for lung cancer

T2 - A systematic review and meta-analysis

AU - Sommer, Maja S.

AU - Staerkind, Maja E. B.

AU - Christensen, Jan

AU - Vibe-Petersen, Jette

AU - Larsen, Klaus R

AU - Holst Pedersen, Jesper

AU - Langberg, Henning

PY - 2018/3

Y1 - 2018/3

N2 - OBJECTIVE: To review the evidence concerning the effects of postoperative exercise interventions on exercise capacity and health-related quality of life following resection for non-small cell lung cancer, and to review whether different initiation times of exercise produce different effects on exercise capacity.DATA SOURCES: Comprehensive literature search of MEDLINE, Embase, CENTRAL, CINAHL and PEDro.STUDY SELECTION: Randomized controlled trials examining the effects of exercise interventions were eligible for inclusion.DATA EXTRACTION: Postoperative outcome measurements were extracted and the quality of evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.DATA SYNTHESIS: Four randomized controlled trials were identified involving 262 participants. Short-term follow-up (12-20 weeks) showed significantly higher exercise capacity and physical component of health-related quality of life in the intervention group (standardized mean difference (SMD) 0.48; 95% confidence interval (CI) 0.04-0.93) compared with the control group (SMD 0.50; 95% CI 0.19-0.82). There was no difference between the effect of late- and early-initiated exercise intervention.CONCLUSION: Exercise has a small-to-moderate effect at short-term follow-up on exercise capacity and the physical component of health-related quality of life in patients operated for lung cancer. The long-term effects of exercise capacity are unknown. Early-initiated exercise programmes (2 weeks post-operation) did not show an effect on exercise capacity. These findings should be interpreted with caution.

AB - OBJECTIVE: To review the evidence concerning the effects of postoperative exercise interventions on exercise capacity and health-related quality of life following resection for non-small cell lung cancer, and to review whether different initiation times of exercise produce different effects on exercise capacity.DATA SOURCES: Comprehensive literature search of MEDLINE, Embase, CENTRAL, CINAHL and PEDro.STUDY SELECTION: Randomized controlled trials examining the effects of exercise interventions were eligible for inclusion.DATA EXTRACTION: Postoperative outcome measurements were extracted and the quality of evidence was graded using Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group.DATA SYNTHESIS: Four randomized controlled trials were identified involving 262 participants. Short-term follow-up (12-20 weeks) showed significantly higher exercise capacity and physical component of health-related quality of life in the intervention group (standardized mean difference (SMD) 0.48; 95% confidence interval (CI) 0.04-0.93) compared with the control group (SMD 0.50; 95% CI 0.19-0.82). There was no difference between the effect of late- and early-initiated exercise intervention.CONCLUSION: Exercise has a small-to-moderate effect at short-term follow-up on exercise capacity and the physical component of health-related quality of life in patients operated for lung cancer. The long-term effects of exercise capacity are unknown. Early-initiated exercise programmes (2 weeks post-operation) did not show an effect on exercise capacity. These findings should be interpreted with caution.

U2 - 10.2340/16501977-2292

DO - 10.2340/16501977-2292

M3 - Review

C2 - 29392334

SN - 1650-1977

VL - 50

SP - 236

EP - 245

JO - Journal of Rehabilitation Medicine

JF - Journal of Rehabilitation Medicine

IS - 3

ER -