Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B12, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial

Nina Rica Wium Geiker; Mette Veller; Louise Kjølbæk; Jette Jakobsen; Christian Ritz; Anne Raben; Arne Astrup; Janne Kunchel Lorenzen; Lesli Hingstrup Larsen; Susanne Gjedsted Bügel

doi:10.1186/s12986-018-0263-1

Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial

Nina Rica Wium Geiker, Mette Veller, Louise Kjølbæk, Jette Jakobsen, Christian Ritz, Anne Raben, Arne Astrup, Janne Kunchel Lorenzen, Lesli Hingstrup Larsen, Susanne Gjedsted Bügel

4 Citationer (Scopus)

74 Downloads (Pure)

Abstract

Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m², completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B₁₂, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results: At baseline, 8% of the participants were deficient in folate, 13% in vitamin B₁₂, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B₁₂ and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion: Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B₁₂ and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration: Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.

Originalsprog	Engelsk
Artikelnummer	24
Tidsskrift	Nutrition & Metabolism
Vol/bind	15
Antal sider	9
ISSN	1743-7075
DOI	https://doi.org/10.1186/s12986-018-0263-1
Status	Udgivet - 10 apr. 2018

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Det Natur- og Biovidenskabelige Fakultet

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10.1186/s12986-018-0263-1Licens: CC BY

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Citationsformater

Geiker, N. R. W., Veller, M., Kjølbæk, L., Jakobsen, J., Ritz, C., Raben, A., Astrup, A., Lorenzen, J. K., Larsen, L. H., & Bügel, S. G. (2018). Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial. Nutrition & Metabolism, 15, Artikel 24. https://doi.org/10.1186/s12986-018-0263-1

Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial. / Geiker, Nina Rica Wium; Veller, Mette; Kjølbæk, Louise et al.
I: Nutrition & Metabolism, Bind 15, 24, 10.04.2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Geiker, NRW, Veller, M, Kjølbæk, L, Jakobsen, J, Ritz, C, Raben, A, Astrup, A, Lorenzen, JK, Larsen, LH & Bügel, SG 2018, 'Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial', Nutrition & Metabolism, bind 15, 24. https://doi.org/10.1186/s12986-018-0263-1

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title = "Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B12, D and E status and the degree of inflammation: a post hoc analysis of a randomized intervention trial",

abstract = "Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results: At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion: Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration: Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.",

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TY - JOUR

T1 - Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B12, D and E status and the degree of inflammation

T2 - a post hoc analysis of a randomized intervention trial

AU - Geiker, Nina Rica Wium

AU - Veller, Mette

AU - Kjølbæk, Louise

AU - Jakobsen, Jette

AU - Ritz, Christian

AU - Raben, Anne

AU - Astrup, Arne

AU - Lorenzen, Janne Kunchel

AU - Larsen, Lesli Hingstrup

AU - Bügel, Susanne Gjedsted

N1 - CURIS 2018 NEXS 126

PY - 2018/4/10

Y1 - 2018/4/10

N2 - Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results: At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion: Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration: Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.

AB - Background: Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. Methods: Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results: At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [- 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion: Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration: Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131.

KW - Faculty of Science

KW - Vitamin status

KW - LED

KW - Homocysteine

KW - C-reactive protein

KW - Fat percentage

KW - Vitamin A

U2 - 10.1186/s12986-018-0263-1

DO - 10.1186/s12986-018-0263-1

M3 - Journal article

C2 - 29643928

SN - 1743-7075

VL - 15

JO - Nutrition & Metabolism

JF - Nutrition & Metabolism

M1 - 24

ER -