Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial

Morten Quist; Maja Schick Sommer; Jette Vibe-Petersen; Maja Bohlbro Stærkind; Seppo W. Langer; Klaus Richter Larsen; Karen Trier; Merete Christensen; Paul F. Clementsen; Malene Missel; Carsten Henriksen; Karl Bang Christensen; Christian Lillelund; Henning Langberg; Jesper H. Pedersen

doi:10.1016/j.lungcan.2018.10.025

Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial

Morten Quist^*, Maja Schick Sommer, Jette Vibe-Petersen, Maja Bohlbro Stærkind, Seppo W. Langer, Klaus Richter Larsen, Karen Trier, Merete Christensen, Paul F. Clementsen, Malene Missel, Carsten Henriksen, Karl Bang Christensen, Christian Lillelund, Henning Langberg, Jesper H. Pedersen

^*Corresponding author af dette arbejde

9 Citationer (Scopus)

Abstract

Introduction: Little is known about the optimal amount and timing of exercise strain in concern of the operation wound and with regard improvement of physical function and quality of life (QOL) after surgery for lung cancer. On this background, we decided to investigate the effect of early vs. late initiated postoperative rehabilitation in patients with operable lung cancer on exercise capacity, functional capacity, muscle strength, and QOL. Methods: The study was designed as a two-armed randomized controlled trial with randomization to either early initiated postoperative rehabilitation (14 days after surgery (ERG)) or a control arm with late initiated postoperative rehabilitation (14 weeks after surgery (LRG)). The primary endpoint was a change in maximum oxygen consumption (VO2peak) from baseline to post intervention 26 weeks following lung resection. Fatigue was measured with EORTC QLQ C30 LC13. Results: From April 2013 to June 2016, 582 patients with operable NSCLC were screened for eligibility. With 119 patients randomized in the early rehabilitation group (ERG) and 116 randomized to late rehabilitation group (LRG). There was no significant difference from baseline to 26 weeks between ERG and LRG (p = 0.926). There was a significant difference from baseline to 14 weeks between groups (p = 0.0018). There was a significant difference from 14 weeks to 26 weeks between the two groups (p < 0.001). We found no significant differences in QOL but we found a significant difference between ERG and LRG from baseline to 14 weeks in fatigue level in favour of ERG. Conclusion: This is the first randomized controlled trial to investigate the effects of early vs. late initiated postoperative rehabilitation in patients with lung cancer. There is no difference in the commencement (early vs. late) of a postoperative exercise program for patients with lung cancer on exercise capacity. But to reduce fatigue patients should be recommended to initiate early exercise programs.

Originalsprog	Engelsk
Tidsskrift	Lung Cancer
Vol/bind	126
Sider (fra-til)	125-132
Antal sider	8
ISSN	0169-5002
DOI	https://doi.org/10.1016/j.lungcan.2018.10.025
Status	Udgivet - 2018

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10.1016/j.lungcan.2018.10.025

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Quist, M., Sommer, M. S., Vibe-Petersen, J., Stærkind, M. B., Langer, S. W., Larsen, K. R., Trier, K., Christensen, M., Clementsen, P. F., Missel, M., Henriksen, C., Christensen, K. B., Lillelund, C., Langberg, H., & Pedersen, J. H. (2018). Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial. Lung Cancer, 126, 125-132. https://doi.org/10.1016/j.lungcan.2018.10.025

Quist, M, Sommer, MS, Vibe-Petersen, J, Stærkind, MB, Langer, SW , Larsen, KR, Trier, K, Christensen, M, Clementsen, PF, Missel, M, Henriksen, C, Christensen, KB, Lillelund, C, Langberg, H & Pedersen, JH 2018, 'Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial', Lung Cancer, bind 126, s. 125-132. https://doi.org/10.1016/j.lungcan.2018.10.025

@article{cedab2823cd445b3865fa8a9f7812b27,

title = "Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial",

abstract = "Introduction: Little is known about the optimal amount and timing of exercise strain in concern of the operation wound and with regard improvement of physical function and quality of life (QOL) after surgery for lung cancer. On this background, we decided to investigate the effect of early vs. late initiated postoperative rehabilitation in patients with operable lung cancer on exercise capacity, functional capacity, muscle strength, and QOL. Methods: The study was designed as a two-armed randomized controlled trial with randomization to either early initiated postoperative rehabilitation (14 days after surgery (ERG)) or a control arm with late initiated postoperative rehabilitation (14 weeks after surgery (LRG)). The primary endpoint was a change in maximum oxygen consumption (VO2peak) from baseline to post intervention 26 weeks following lung resection. Fatigue was measured with EORTC QLQ C30 LC13. Results: From April 2013 to June 2016, 582 patients with operable NSCLC were screened for eligibility. With 119 patients randomized in the early rehabilitation group (ERG) and 116 randomized to late rehabilitation group (LRG). There was no significant difference from baseline to 26 weeks between ERG and LRG (p = 0.926). There was a significant difference from baseline to 14 weeks between groups (p = 0.0018). There was a significant difference from 14 weeks to 26 weeks between the two groups (p < 0.001). We found no significant differences in QOL but we found a significant difference between ERG and LRG from baseline to 14 weeks in fatigue level in favour of ERG. Conclusion: This is the first randomized controlled trial to investigate the effects of early vs. late initiated postoperative rehabilitation in patients with lung cancer. There is no difference in the commencement (early vs. late) of a postoperative exercise program for patients with lung cancer on exercise capacity. But to reduce fatigue patients should be recommended to initiate early exercise programs.",

keywords = "Fatigue, Lung cancer, Post operative exercise",

author = "Morten Quist and Sommer, {Maja Schick} and Jette Vibe-Petersen and St{\ae}rkind, {Maja Bohlbro} and Langer, {Seppo W.} and Larsen, {Klaus Richter} and Karen Trier and Merete Christensen and Clementsen, {Paul F.} and Malene Missel and Carsten Henriksen and Christensen, {Karl Bang} and Christian Lillelund and Henning Langberg and Pedersen, {Jesper H.}",

year = "2018",

doi = "10.1016/j.lungcan.2018.10.025",

language = "English",

volume = "126",

pages = "125--132",

journal = "Lung Cancer",

issn = "0169-5002",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer

T2 - A randomized trial

AU - Quist, Morten

AU - Sommer, Maja Schick

AU - Vibe-Petersen, Jette

AU - Stærkind, Maja Bohlbro

AU - Langer, Seppo W.

AU - Larsen, Klaus Richter

AU - Trier, Karen

AU - Christensen, Merete

AU - Clementsen, Paul F.

AU - Missel, Malene

AU - Henriksen, Carsten

AU - Christensen, Karl Bang

AU - Lillelund, Christian

AU - Langberg, Henning

AU - Pedersen, Jesper H.

PY - 2018

Y1 - 2018

N2 - Introduction: Little is known about the optimal amount and timing of exercise strain in concern of the operation wound and with regard improvement of physical function and quality of life (QOL) after surgery for lung cancer. On this background, we decided to investigate the effect of early vs. late initiated postoperative rehabilitation in patients with operable lung cancer on exercise capacity, functional capacity, muscle strength, and QOL. Methods: The study was designed as a two-armed randomized controlled trial with randomization to either early initiated postoperative rehabilitation (14 days after surgery (ERG)) or a control arm with late initiated postoperative rehabilitation (14 weeks after surgery (LRG)). The primary endpoint was a change in maximum oxygen consumption (VO2peak) from baseline to post intervention 26 weeks following lung resection. Fatigue was measured with EORTC QLQ C30 LC13. Results: From April 2013 to June 2016, 582 patients with operable NSCLC were screened for eligibility. With 119 patients randomized in the early rehabilitation group (ERG) and 116 randomized to late rehabilitation group (LRG). There was no significant difference from baseline to 26 weeks between ERG and LRG (p = 0.926). There was a significant difference from baseline to 14 weeks between groups (p = 0.0018). There was a significant difference from 14 weeks to 26 weeks between the two groups (p < 0.001). We found no significant differences in QOL but we found a significant difference between ERG and LRG from baseline to 14 weeks in fatigue level in favour of ERG. Conclusion: This is the first randomized controlled trial to investigate the effects of early vs. late initiated postoperative rehabilitation in patients with lung cancer. There is no difference in the commencement (early vs. late) of a postoperative exercise program for patients with lung cancer on exercise capacity. But to reduce fatigue patients should be recommended to initiate early exercise programs.

AB - Introduction: Little is known about the optimal amount and timing of exercise strain in concern of the operation wound and with regard improvement of physical function and quality of life (QOL) after surgery for lung cancer. On this background, we decided to investigate the effect of early vs. late initiated postoperative rehabilitation in patients with operable lung cancer on exercise capacity, functional capacity, muscle strength, and QOL. Methods: The study was designed as a two-armed randomized controlled trial with randomization to either early initiated postoperative rehabilitation (14 days after surgery (ERG)) or a control arm with late initiated postoperative rehabilitation (14 weeks after surgery (LRG)). The primary endpoint was a change in maximum oxygen consumption (VO2peak) from baseline to post intervention 26 weeks following lung resection. Fatigue was measured with EORTC QLQ C30 LC13. Results: From April 2013 to June 2016, 582 patients with operable NSCLC were screened for eligibility. With 119 patients randomized in the early rehabilitation group (ERG) and 116 randomized to late rehabilitation group (LRG). There was no significant difference from baseline to 26 weeks between ERG and LRG (p = 0.926). There was a significant difference from baseline to 14 weeks between groups (p = 0.0018). There was a significant difference from 14 weeks to 26 weeks between the two groups (p < 0.001). We found no significant differences in QOL but we found a significant difference between ERG and LRG from baseline to 14 weeks in fatigue level in favour of ERG. Conclusion: This is the first randomized controlled trial to investigate the effects of early vs. late initiated postoperative rehabilitation in patients with lung cancer. There is no difference in the commencement (early vs. late) of a postoperative exercise program for patients with lung cancer on exercise capacity. But to reduce fatigue patients should be recommended to initiate early exercise programs.

KW - Fatigue

KW - Lung cancer

KW - Post operative exercise

U2 - 10.1016/j.lungcan.2018.10.025

DO - 10.1016/j.lungcan.2018.10.025

M3 - Journal article

C2 - 30527176

AN - SCOPUS:85056447408

SN - 0169-5002

VL - 126

SP - 125

EP - 132

JO - Lung Cancer

JF - Lung Cancer

ER -

Early initiated postoperative rehabilitation reduces fatigue in patients with operable lung cancer: A randomized trial

Abstract

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