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Dose Finding in the Clinical Development of 60 US Food and Drug Administration-Approved Drugs Compared With Learning vs. Confirming Recommendations
Yassine Kamal Lyauk
, Daniël Martijn Jonker,
Trine Meldgaard Lund
3
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Keyphrases
Clinical Development
100%
Dose Finding
100%
Dose Exposure
100%
Exposure-response
100%
U.S. Food
100%
Approved Drugs
100%
Preclinical Development
50%
First-in-patient
50%
Dose-finding Trial
50%
Dose-ranging
50%
Response Evaluation
25%
Clinical Development Programs
25%
Dose number
25%
Development Paradigm
25%
Multiple Dose
25%
Drug Development Program
25%
Model-based Approach
25%
Dose-response
25%
Risk-benefit
25%
Development Practice
25%
Confirmatory Trials
25%
Pharmacology, Toxicology and Pharmaceutical Science
Drug Development
100%