@article{fe17ca70519211dd8d9f000ea68e967b,
title = "DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis.",
abstract = "We propose a model for heterochromatin assembly that links DNA methylation with histone methylation and DNA replication. The hypomethylated Arabidopsis mutants ddm1 and met1 were used to investigate the relationship between DNA methylation and chromatin organization. Both mutants show a reduction of heterochromatin due to dispersion of pericentromeric low-copy sequences away from heterochromatic chromocenters. DDM1 and MET1 control heterochromatin assembly at chromocenters by their influence on DNA maintenance (CpG) methylation and subsequent methylation of histone H3 lysine 9. In addition, DDM1 is required for deacetylation of histone H4 lysine 16. Analysis of F(1) hybrids between wild-type and hypomethylated mutants revealed that DNA methylation is epigenetically inherited and represents the genomic imprint that is required to maintain pericentromeric heterochromatin.",
author = "Soppe, {Wim J J} and Zusana Jasencakova and Andreas Houben and Tetsuji Kakutani and Armin Meister and Huang, {Michael S} and Jacobsen, {Steven E} and Ingo Schubert and Fransz, {Paul F}",
note = "Keywords: Arabidopsis; Arabidopsis Proteins; DNA Methylation; DNA-Binding Proteins; Gene Silencing; Heterochromatin; Histones; Mutation; Transcription Factors",
year = "2002",
language = "English",
volume = "21",
pages = "6549--59",
journal = "E M B O Journal",
issn = "0261-4189",
publisher = "Wiley-Blackwell",
number = "23",
}