Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

Aaron M Bender, Hyekyung P Cho, Kellie D Nance, Kaelyn S Lingenfelter, Vincent B Luscombe, Patrick R Gentry, Karl Voigtritter, Alice E Berizzi, Patrick M Sexton, Christopher J Langmead, Arthur Christopoulos, Charles W Locuson, Thomas M Bridges, Sichen Chang, Jordan C O'Neill, Xiaoyan Zhan, Colleen M Niswender, Carrie K Jones, P Jeffrey Conn, Craig W Lindsley