Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells

Medicin og biovidenskab

• Early-onset ataxia with oculomotor apraxia and hypoalbuminemia 100%
• Autosomal recessive 1 Spinocerebellar ataxia 95%
• Autosomal Dominant Optic Atrophy 42%
• Membrane Fusion Proteins 41%
• Homeostasis 38%
• Mitophagy 35%
• Spinocerebellar Ataxias 35%
• Oxidative Phosphorylation 29%
• Adenosine Monophosphate 29%
• DNA Replication 26%
• DNA Repair 24%
• Ligation 23%
• Neurodegenerative Diseases 22%
• Mitochondria 21%
• Pathology 16%
• Mutation 14%
• DNA 14%