Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers: the Eurodiale study

TY - JOUR

T1 - Diabetic complications do not hamper improvement of health-related quality of life over the course of treatment of diabetic foot ulcers

T2 - the Eurodiale study

AU - Siersma, Volkert

AU - Thorsen, Hanne

AU - Holstein, Per E.

AU - Kars, Marleen

AU - Apelqvist, Jan

AU - Jude, Edward B.

AU - Piaggesi, Alberto

AU - Bakker, Karel

AU - Edmonds, Michael

AU - Jirkovská, Alexandra

AU - Mauricio, Didac

AU - Reike, Heinrich

AU - Spraul, Maximilian

AU - Uccioli, Luigi

AU - Urbancic, Vilma

AU - van Acker, Kristien

AU - van Baal, Jeff

AU - Schaper, Nicolaas C.

PY - 2017/7

Y1 - 2017/7

N2 - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.

AB - Aims: Diabetic complications, and in particular diabetic foot ulcers (DFUs), are associated with low health-related quality of life (HRQoL). We evaluated whether the presence of diabetic complications also influenced the improvement of HRQoL during DFU treatment. Methods: 1088 patients presenting for DFU treatment at the centers participating in the Eurodiale study were followed prospectively up to one year. HRQoL was measured both at presentation and after healing or at end of follow up, using EQ-5D: a standardized instrument consisting of five domains and a summary index. The influence of diabetic comorbidity on the course of HRQoL was evaluated for each of the EQ-5D outcomes in multi-level linear regression analyses, adjusting for baseline characteristics. Results: HRQoL improved in all EQ-5D outcomes over the course of treatment for those DFUs that healed. The few significant differences in the development of HRQoL between patients with and without comorbidity showed a more beneficial development for patients with comorbidity in DFUs that did not heal or healed slowly. Conclusions: Comorbidity does not hamper improvement of HRQoL in DFU treatment. On the contrary, HRQoL improved sometimes more in patients with certain comorbidity with hard-to-heal ulcers.

KW - Comorbidity

KW - Diabetes mellitus

KW - Diabetic foot ulcer

KW - Health-related quality of life

KW - Longitudinal study

U2 - 10.1016/j.jdiacomp.2017.04.008

DO - 10.1016/j.jdiacomp.2017.04.008

M3 - Journal article

C2 - 28457703

AN - SCOPUS:85018320443

SN - 1056-8727

VL - 31

SP - 1145

EP - 1151

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 7

ER -