Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC₂₀₁₀ ) Mother-Child Cohort

TY - JOUR

T1 - Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort

AU - Bjarnadóttir, Elín

AU - Stokholm, Jakob

AU - Chawes, Bo

AU - Thorsen, Jonathan

AU - Mora-Jensen, Anna Rosa Cecilie

AU - Deleuran, Maja

AU - Bønnelykke, Klaus

AU - Lauritzen, Lotte

AU - Bisgaard, Hans

N1 - CURIS 2019 NEXS 106 This article is protected by copyright. All rights reserved.

PY - 2019

Y1 - 2019

N2 - Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child. Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age. Results: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1-year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2-year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02). Conclusion: Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.

AB - Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child. Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother–child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age. Results: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1-year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2-year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02). Conclusion: Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.

KW - Faculty of Science

KW - Cognitive development

KW - Language development

KW - Motor development

KW - Neurological development

U2 - 10.1111/apa.14753

DO - 10.1111/apa.14753

M3 - Journal article

C2 - 30748036

SN - 0803-5253

VL - 108

SP - 1632

EP - 1641

JO - Acta Paediatrica

JF - Acta Paediatrica

IS - 9

ER -