Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Betina Elfving; Henriette Nørmølle Buttenschøn; Leslie Foldager; Pia H P Poulsen; Niels Johan Andersen; Matias Brødsgaard Grynderup; Åse M Hansen; Henrik A. Kolstad; Linda Kaerlev; Sigurd Mikkelsen; Jane F Thomsen; Anders Børglum; Gregers Wegener; Ole Mors

doi:10.1016/j.jpsychires.2012.05.003

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Betina Elfving, Henriette Nørmølle Buttenschøn, Leslie Foldager, Pia H P Poulsen, Niels Johan Andersen, Matias Brødsgaard Grynderup, Åse M Hansen, Henrik A. Kolstad, Linda Kaerlev, Sigurd Mikkelsen, Jane F Thomsen, Anders Børglum, Gregers Wegener, Ole Mors

47 Citationer (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.

Originalsprog	Engelsk
Tidsskrift	Journal of Psychiatric Research
Vol/bind	46
Udgave nummer	9
Sider (fra-til)	1118-25
Antal sider	8
ISSN	0022-3956
DOI	https://doi.org/10.1016/j.jpsychires.2012.05.003
Status	Udgivet - sep. 2012

Adgang til dokumentet

10.1016/j.jpsychires.2012.05.003

Citationsformater

Elfving, B., Buttenschøn, H. N., Foldager, L., Poulsen, P. H. P., Andersen, N. J., Grynderup, M. B., Hansen, Å. M., Kolstad, H. A., Kaerlev, L., Mikkelsen, S., Thomsen, J. F., Børglum, A., Wegener, G., & Mors, O. (2012). Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level. Journal of Psychiatric Research, 46(9), 1118-25. https://doi.org/10.1016/j.jpsychires.2012.05.003

Elfving, B, Buttenschøn, HN, Foldager, L, Poulsen, PHP, Andersen, NJ, Grynderup, MB, Hansen, ÅM, Kolstad, HA, Kaerlev, L, Mikkelsen, S, Thomsen, JF, Børglum, A, Wegener, G & Mors, O 2012, 'Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level', Journal of Psychiatric Research, bind 46, nr. 9, s. 1118-25. https://doi.org/10.1016/j.jpsychires.2012.05.003

@article{0df6498c29ba451497150c5b4cf9b083,

title = "Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level",

abstract = "Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.",

keywords = "Adult, Aging, Analysis of Variance, Brain-Derived Neurotrophic Factor, Depression, Female, Genetic Association Studies, Genotype, Humans, Life Style, Male, Methionine, Middle Aged, Polymorphism, Single Nucleotide, Questionnaires, Regression Analysis, Sex Characteristics, Valine",

author = "Betina Elfving and Buttensch{\o}n, {Henriette N{\o}rm{\o}lle} and Leslie Foldager and Poulsen, {Pia H P} and Andersen, {Niels Johan} and Grynderup, {Matias Br{\o}dsgaard} and Hansen, {{\AA}se M} and Kolstad, {Henrik A.} and Linda Kaerlev and Sigurd Mikkelsen and Thomsen, {Jane F} and Anders B{\o}rglum and Gregers Wegener and Ole Mors",

year = "2012",

month = sep,

doi = "10.1016/j.jpsychires.2012.05.003",

language = "English",

volume = "46",

pages = "1118--25",

journal = "Journal of Psychiatric Research",

issn = "0022-3956",

publisher = "Pergamon Press",

number = "9",

}

TY - JOUR

T1 - Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

AU - Elfving, Betina

AU - Buttenschøn, Henriette Nørmølle

AU - Foldager, Leslie

AU - Poulsen, Pia H P

AU - Andersen, Niels Johan

AU - Grynderup, Matias Brødsgaard

AU - Hansen, Åse M

AU - Kolstad, Henrik A.

AU - Kaerlev, Linda

AU - Mikkelsen, Sigurd

AU - Thomsen, Jane F

AU - Børglum, Anders

AU - Wegener, Gregers

AU - Mors, Ole

PY - 2012/9

Y1 - 2012/9

N2 - Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.

AB - Brain-derived neurotrophic factor (BDNF) has been suggested as a candidate gene for depression and numerous studies have investigated the possible association between genetic variants within BDNF and depression. Clinical studies have investigated the serum BDNF levels in individuals with depression. However, few studies have combined genetic association studies with serum BDNF measurements. The purpose of the present study was therefore to perform an investigation of BDNF using 162 individuals with depression and 289 healthy individuals. All individuals returned a completed questionnaire and participated in a semi-structured diagnostic interview. The major contribution of the present study is the integration of clinical assessment of cases and control individuals, simultaneous analyses of several genetic variants, serum BDNF measurements, and information on socio-demographic variables, lifestyle, and health indicators in a statistical model. In the present study the serum BDNF levels were increased in the depressive subjects compared to control individuals. Additionally, six SNPs were successfully analyzed, but did not associate with depression. Multiple linear regression models were applied and age, depression, gender, the Val66Met polymorphism, and the interaction between Val66Met and gender were identified as significant determinants of the serum BDNF level. In conclusion, our data demonstrate that other factors than a diagnosis of depression influence the serum BDNF level and the importance of these factors should be emphasized comparing different studies.

KW - Adult

KW - Aging

KW - Analysis of Variance

KW - Brain-Derived Neurotrophic Factor

KW - Depression

KW - Female

KW - Genetic Association Studies

KW - Genotype

KW - Humans

KW - Life Style

KW - Male

KW - Methionine

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Questionnaires

KW - Regression Analysis

KW - Sex Characteristics

KW - Valine

U2 - 10.1016/j.jpsychires.2012.05.003

DO - 10.1016/j.jpsychires.2012.05.003

M3 - Journal article

C2 - 22682508

SN - 0022-3956

VL - 46

SP - 1118

EP - 1125

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 9

ER -

Depression, the Val66Met polymorphism, age, and gender influence the serum BDNF level

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater