Decreased Leakage Rate of Colonic Anastomoses by Tachosil Coating: An Experimental Study

Hans-Christian Pommergaard; Michael Patrick Achiam; Jakob Burcharth; Jacob Rosenberg

doi:10.9738/INTSURG-D-13-00093.1

Decreased Leakage Rate of Colonic Anastomoses by Tachosil Coating: An Experimental Study

Hans-Christian Pommergaard, Michael Patrick Achiam, Jakob Burcharth, Jacob Rosenberg

Institut for Klinisk Medicin

3 Citationer (Scopus)

Abstract

Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P=0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P<0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P=0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.

Originalsprog	Engelsk
Tidsskrift	International Surgery
Vol/bind	99
Udgave nummer	4
Sider (fra-til)	359-363
Antal sider	5
ISSN	0020-8868
DOI	https://doi.org/10.9738/INTSURG-D-13-00093.1
Status	Udgivet - 25 jul. 2014

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10.9738/INTSURG-D-13-00093.1

Citationsformater

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title = "Decreased Leakage Rate of Colonic Anastomoses by Tachosil Coating: An Experimental Study",

abstract = "Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P=0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P<0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P=0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.",

author = "Hans-Christian Pommergaard and Achiam, {Michael Patrick} and Jakob Burcharth and Jacob Rosenberg",

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T1 - Decreased Leakage Rate of Colonic Anastomoses by Tachosil Coating

T2 - An Experimental Study

AU - Pommergaard, Hans-Christian

AU - Achiam, Michael Patrick

AU - Burcharth, Jakob

AU - Rosenberg, Jacob

PY - 2014/7/25

Y1 - 2014/7/25

N2 - Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P=0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P<0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P=0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.

AB - Colorectal anastomotic coating has been proposed as a means to lower the leakage rate. Prior to clinical testing, coating materials need thorough experimental evaluation to ensure safety and efficacy. The aim of this study was to evaluate Tachosil as an anastomotic coating agent. Technically insufficient colon anastomoses were created in 80 C57BL/6 mice, and in half of the animals the anastomoses were covered with Tachosil. The animals were examined for clinical signs of anastomotic leakage, and the breaking strength of the anastomoses was evaluated. The number of leakages was reduced by Tachosil coating (10/40 versus 20/40 in controls; P=0.037). However, more cases of large bowel obstruction were found in the Tachosil group (12/40 versus 0/40 in controls; P<0.0005). Breaking strength was comparable between the Tachosil and control groups (0.49 N versus 0.52 N, respectively; P=0.423). Clinical studies are needed to clarify the efficacy of Tachosil anastomotic coating.

U2 - 10.9738/INTSURG-D-13-00093.1

DO - 10.9738/INTSURG-D-13-00093.1

M3 - Journal article

C2 - 25058765

SN - 0020-8868

VL - 99

SP - 359

EP - 363

JO - International Surgery

JF - International Surgery

IS - 4

ER -

Decreased Leakage Rate of Colonic Anastomoses by Tachosil Coating: An Experimental Study

Abstract

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