Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

D. Mathur; N. Rana; Carl Erik Olsen; V. S. Parmar; A. K. Prasad

doi:10.1002/jhet.2159

Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

D. Mathur, N. Rana, Carl Erik Olsen, V. S. Parmar, A. K. Prasad

Plantebiokemi

7 Citationer (Scopus)

Abstract

A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

Originalsprog	Engelsk
Tidsskrift	Journal of Heterocyclic Chemistry
Vol/bind	52
Udgave nummer	3
Sider (fra-til)	701-710
Antal sider	10
ISSN	1943-5193
DOI	https://doi.org/10.1002/jhet.2159
Status	Udgivet - 1 maj 2015

Adgang til dokumentet

10.1002/jhet.2159

Citationsformater

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title = "Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates",

abstract = "A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.",

author = "D. Mathur and N. Rana and Olsen, {Carl Erik} and Parmar, {V. S.} and Prasad, {A. K.}",

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T1 - Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

AU - Mathur, D.

AU - Rana, N.

AU - Olsen, Carl Erik

AU - Parmar, V. S.

AU - Prasad, A. K.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

AB - A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

U2 - 10.1002/jhet.2159

DO - 10.1002/jhet.2159

M3 - Journal article

SN - 0022-152X

VL - 52

SP - 701

EP - 710

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 3

ER -