Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

D. Mathur; N. Rana; Carl Erik Olsen; V. S. Parmar; A. K. Prasad

doi:10.1002/jhet.2159

Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

D. Mathur, N. Rana, Carl Erik Olsen, V. S. Parmar, A. K. Prasad

Section for Plant Biochemistry

7 Citations (Scopus)

Abstract

A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

Original language	English
Journal	Journal of Heterocyclic Chemistry
Volume	52
Issue number	3
Pages (from-to)	701-710
Number of pages	10
ISSN	1943-5193
DOIs	https://doi.org/10.1002/jhet.2159
Publication status	Published - 1 May 2015

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10.1002/jhet.2159

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title = "Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates",

abstract = "A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.",

author = "D. Mathur and N. Rana and Olsen, {Carl Erik} and Parmar, {V. S.} and Prasad, {A. K.}",

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T1 - Cu(I)-catalyzed efficient synthesis of 2′-Triazolo-nucleoside conjugates

AU - Mathur, D.

AU - Rana, N.

AU - Olsen, Carl Erik

AU - Parmar, V. S.

AU - Prasad, A. K.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

AB - A small library of thirty-two 2′-triazolyl uridine and 2′-triazolyl-5-methyluridine has been synthesized by Cu(I)-catalyzed condensation of 2′-azido-2′-deoxyuridine and 2′-azido-2′-deoxy-5-methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo-nucleoside conjugates, which can be evaluated for different biological activity for suitable drug development, were unambiguously identified on the basis of 1H NMR, 13C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.

U2 - 10.1002/jhet.2159

DO - 10.1002/jhet.2159

M3 - Journal article

SN - 0022-152X

VL - 52

SP - 701

EP - 710

JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 3

ER -