Crystallization of Piroxicam Solid Forms and the Effects of Additives

Guangpu Liu; Thomas B. Hansen; Haiyan Qu; Mingshi Yang; Jari P. Pajander; Jukka Rantanen; Lars P. Christensen

doi:10.1002/ceat.201400206

Crystallization of Piroxicam Solid Forms and the Effects of Additives

Guangpu Liu, Thomas B. Hansen, Haiyan Qu^*, Mingshi Yang, Jari P. Pajander, Jukka Rantanen, Lars P. Christensen

^*Corresponding author af dette arbejde

17 Citationer (Scopus)

Abstract

The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δ_T and the hydrogen bonding solubility parameter δ_H of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δ_T and δ_H parameters similar to those of piroxicam.

Originalsprog	Engelsk
Tidsskrift	Chemical Engineering and Technology
Vol/bind	37
Udgave nummer	8
Sider (fra-til)	1297-1304
Antal sider	8
ISSN	0930-7516
DOI	https://doi.org/10.1002/ceat.201400206
Status	Udgivet - 2014

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10.1002/ceat.201400206

Citationsformater

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title = "Crystallization of Piroxicam Solid Forms and the Effects of Additives",

abstract = "The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.",

keywords = "Crystallization, Effect of additives, Monohydrate, Pharmaceutical products, Polymorphism, Relative thermodynamic stability",

author = "Guangpu Liu and Hansen, {Thomas B.} and Haiyan Qu and Mingshi Yang and Pajander, {Jari P.} and Jukka Rantanen and Christensen, {Lars P.}",

year = "2014",

doi = "10.1002/ceat.201400206",

language = "English",

volume = "37",

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TY - JOUR

T1 - Crystallization of Piroxicam Solid Forms and the Effects of Additives

AU - Liu, Guangpu

AU - Hansen, Thomas B.

AU - Qu, Haiyan

AU - Yang, Mingshi

AU - Pajander, Jari P.

AU - Rantanen, Jukka

AU - Christensen, Lars P.

PY - 2014

Y1 - 2014

N2 - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

AB - The relative stabilities of the two anhydrous polymorphs and the monohydrate of piroxicam in ethanol/water mixtures and the crystallization behavior of the solid forms in the presence of 11 additives were studied. At 37°C, formII is thermodynamically more stable than formI, while the relative stability of formII and the monohydrate depends on the water concentration in the solution. The total Hansen solubility parameter δT and the hydrogen bonding solubility parameter δH of the substances can partly explain the effects of the additives on the crystallization of the solid forms. The additives that selectively promoted the crystallization of formI are the ones with δT and δH parameters similar to those of piroxicam.

KW - Crystallization

KW - Effect of additives

KW - Monohydrate

KW - Pharmaceutical products

KW - Polymorphism

KW - Relative thermodynamic stability

U2 - 10.1002/ceat.201400206

DO - 10.1002/ceat.201400206

M3 - Journal article

AN - SCOPUS:84904806350

SN - 0930-7516

VL - 37

SP - 1297

EP - 1304

JO - Chemical Engineering and Technology

JF - Chemical Engineering and Technology

IS - 8

ER -

Crystallization of Piroxicam Solid Forms and the Effects of Additives

Abstract

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