Corticomuscular coherence in the acute and subacute phase after stroke

TY - JOUR

T1 - Corticomuscular coherence in the acute and subacute phase after stroke

AU - Larsen, Lisbeth Hoejkjaer

AU - Zibrandtsen, Ivan Chrilles

AU - Wienecke, Troels

AU - Kjaer, Troels Wesenberg

AU - Christensen, Mark Schram

AU - Nielsen, Jens Bo

AU - Langberg, Henning

N1 - Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2017/11

Y1 - 2017/11

N2 - OBJECTIVE: Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke.METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand.RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC.CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke.SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.

AB - OBJECTIVE: Stroke is one of the leading causes of physical disability due to damage of the motor cortex or the corticospinal tract. In the present study we set out to investigate the role of adaptations in the corticospinal pathway for motor recovery during the subacute phase after stroke.METHODS: We examined 19 patients with clinically diagnosed stroke and 18 controls. The patients had unilateral mild to moderate weakness of the hand. Each patient attended two sessions at approximately 3days (acute) and 38days post stroke (subacute). Task-related changes in the communication between motor cortex and muscles were evaluated from coupling in the frequency domain between EEG and EMG during movement of the paretic hand.RESULTS: Corticomuscular coherence (CMC) and intermuscular coherence (IMC) were reduced in patients as compared to controls. Paretic hand motor performance improved within 4-6weeks after stroke, but no change was observed in CMC or IMC.CONCLUSIONS: CMC and IMC were reduced in patients in the early phase after stroke. However, changes in coherence do not appear to be an efficient marker for early recovery of hand function following stroke.SIGNIFICANCE: This is the first study to demonstrate sustained reduced coherence in acute and subacute stroke.

U2 - 10.1016/j.clinph.2017.08.033

DO - 10.1016/j.clinph.2017.08.033

M3 - Journal article

C2 - 28987993

SN - 1388-2457

VL - 128

SP - 2217

EP - 2226

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 11

ER -