@article{4f8812e05d4411dd8d9f000ea68e967b,
title = "Colour development of immunogold-labelled antibodies for light microscopy.",
abstract = "We describe an improvement of the immunogold technique, which is based on the colour development of silver-intensified immunogold signals. This method (referred to as the coloured-SIG technique) was found to be as sensitive as the silver-intensified immunogold method and more sensitive (in two of the three tested systems) than immunoenzymatic procedures, such as the peroxidase/antiperoxidase technique or the avidin-biotin system. The coloured SIG-method results in either a magenta-red or a cyan-blue final reaction product. Therefore, this new improvement of the immunogold technique should be useful in double-staining methods, immunoblot methods and conventional immunostaining methods.",
author = "P Fritz and J Hoenes and J Schenk and A Mischlinski and A Grau and Saal, {J G} and Tuczek, {H V} and H Multhaupt and G Pfleiderer",
note = "Keywords: Antibodies; Antigens, Surface; Arthritis, Rheumatoid; Gold; Humans; Immunoenzyme Techniques; Microscopy; Osteoarthritis; Synovial Membrane; T-Lymphocytes; Tonsil",
year = "1986",
language = "English",
volume = "85",
pages = "209--14",
journal = "Histochemistry",
issn = "0301-5564",
publisher = "Springer",
number = "3",
}