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Co-former selection for co-amorphous drug-amino acid formulations
Georgia Kasten,
Korbinian Löbmann
,
Holger Grohganz
,
Thomas Rades
21
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Keyphrases
Amorphization
100%
Amorphous Drug
100%
Physical Stability
100%
Amino Acid Complex
100%
Intrinsic Dissolution Rate
83%
Amorphous Formulation
66%
Phenylalanine
33%
Dissolution Rate
33%
Tryptophan
33%
Leucine
33%
Formability
33%
Differential Scanning Calorimetry
16%
Critical Quality Attributes
16%
Acidic Drugs
16%
Valine
16%
Drying Conditions
16%
Lysine
16%
Arginine
16%
Glass Transition Temperature
16%
Fast Screening Method
16%
Histidine
16%
Aromatic Groups
16%
Methionine
16%
Thermal Behavior
16%
Phosphate Buffer
16%
X-ray Powder Diffraction
16%
Ball Milling
16%
Amino Acids
16%
Pharmacology, Toxicology and Pharmaceutical Science
Phenylalanine
100%
Tryptophan
100%
Amino Acid
100%
Lysine
50%
Leucine
50%
Isoleucine
50%
Methionine
50%
Buffer
50%
Histidine
50%
Differential Scanning Calorimetry
50%
Arginine
50%
Drug
50%
Valine
50%