Cholecystokinin expression in tumors: biogenetic and diagnostic implications

Jens F Rehfeld

doi:10.2217/fon-2015-0053

Cholecystokinin expression in tumors: biogenetic and diagnostic implications

Jens F Rehfeld

Institut for Klinisk Medicin

6 Citationer (Scopus)

Abstract

Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.

Originalsprog	Engelsk
Tidsskrift	Future Oncology
Vol/bind	12
Udgave nummer	18
Sider (fra-til)	2135-47
Antal sider	13
ISSN	1479-6694
DOI	https://doi.org/10.2217/fon-2015-0053
Status	Udgivet - sep. 2016

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10.2217/fon-2015-0053

Citationsformater

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title = "Cholecystokinin expression in tumors: biogenetic and diagnostic implications",

abstract = "Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.",

keywords = "Biomarkers, Tumor, Cell Proliferation, Cholecystokinin, Gene Expression Regulation, Neoplastic, Humans, Multigene Family, Neoplasms, Prognosis, Protein Binding, Protein Processing, Post-Translational, Protein Transport, RNA, Messenger, Receptors, Cholecystokinin, Journal Article, Review",

author = "Rehfeld, {Jens F}",

year = "2016",

month = sep,

doi = "10.2217/fon-2015-0053",

language = "English",

volume = "12",

pages = "2135--47",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Future Medicine Ltd.",

number = "18",

}

TY - JOUR

T1 - Cholecystokinin expression in tumors

T2 - biogenetic and diagnostic implications

AU - Rehfeld, Jens F

PY - 2016/9

Y1 - 2016/9

N2 - Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.

AB - Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.

KW - Biomarkers, Tumor

KW - Cell Proliferation

KW - Cholecystokinin

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Multigene Family

KW - Neoplasms

KW - Prognosis

KW - Protein Binding

KW - Protein Processing, Post-Translational

KW - Protein Transport

KW - RNA, Messenger

KW - Receptors, Cholecystokinin

KW - Journal Article

KW - Review

U2 - 10.2217/fon-2015-0053

DO - 10.2217/fon-2015-0053

M3 - Review

C2 - 27306028

SN - 1479-6694

VL - 12

SP - 2135

EP - 2147

JO - Future Oncology

JF - Future Oncology

IS - 18

ER -

Cholecystokinin expression in tumors: biogenetic and diagnostic implications

Abstract

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