Abstract
Cholecystokinin (CCK) is a classic gut hormone. CCK is also a complex system of peptides expressed in several molecular forms in enteroendocrine I cells, in cerebral and peripheral neurons, in cardiac myocytes and spermatozoa. CCK gene expression has now been found at protein or peptide level in different neuroendocrine tumors; cerebral gliomas and astrocytomas and specific pediatric tumors. Tumor hypersecretion of CCK was recently reported in a patient with a metastatic islet cell tumor and hypercholecystokininemia resulting in a novel tumor syndrome, the cholecystokininoma syndrome. This review presents an overview of the cell-specific biogenesis of CCK peptides, and a description of the CCK expression in tumors and of the cholecystokininoma syndrome. Finally, assays for the diagnosis of CCK-producing tumors are reviewed.
| Original language | English |
|---|---|
| Journal | Future Oncology |
| Volume | 12 |
| Issue number | 18 |
| Pages (from-to) | 2135-47 |
| Number of pages | 13 |
| ISSN | 1479-6694 |
| DOIs | |
| Publication status | Published - Sept 2016 |
Keywords
- Biomarkers, Tumor
- Cell Proliferation
- Cholecystokinin
- Gene Expression Regulation, Neoplastic
- Humans
- Multigene Family
- Neoplasms
- Prognosis
- Protein Binding
- Protein Processing, Post-Translational
- Protein Transport
- RNA, Messenger
- Receptors, Cholecystokinin
- Journal Article
- Review