Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

TY - JOUR

T1 - Changing M3G/M6G ratios and pharmacodynamics in a cancer patient during long-term morphine treatment

AU - Andersen, Gertrud

AU - Christrup, Lona Louring

AU - Sjøgren, Per

AU - Hansen, Steen Honoré

AU - Jensen, Niels-Henrik

PY - 2002/2

Y1 - 2002/2

N2 - A cancer patient receiving long-term oral sustained-release morphine treatment and periodically presenting with unusually high plasma M3G/M6G ratios is described. We found the patient's formation of M6G more unstable and perhaps delayed compared to the formation of M3G. There is no apparent explanation for this phenomenon and the high M3G/M6G ratios had no implications for the patient's pain experience or side effects from the morphine treatment.

AB - A cancer patient receiving long-term oral sustained-release morphine treatment and periodically presenting with unusually high plasma M3G/M6G ratios is described. We found the patient's formation of M6G more unstable and perhaps delayed compared to the formation of M3G. There is no apparent explanation for this phenomenon and the high M3G/M6G ratios had no implications for the patient's pain experience or side effects from the morphine treatment.

KW - Analgesics, Opioid

KW - Central Nervous System Stimulants

KW - Humans

KW - Male

KW - Middle Aged

KW - Morphine

KW - Morphine Derivatives

KW - Pain

KW - Prostatic Neoplasms

KW - Time Factors

M3 - Journal article

C2 - 11844638

SN - 0885-3924

VL - 23

SP - 161

EP - 164

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

IS - 2

ER -