Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs

Ann Cathrine Findal Støy; Peter M. H. Heegaard; Thomas Thymann; Mette Bjerre; Kerstin Skovgaard; Mette Boye; Barbara Stoll; Mette Schmidt; Bent B Jensen; Per Torp Sangild

doi:10.1016/j.clnu.2013.05.013

Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs

Ann Cathrine Findal Støy, Peter M. H. Heegaard, Thomas Thymann, Mette Bjerre, Kerstin Skovgaard, Mette Boye, Barbara Stoll, Mette Schmidt, Bent B Jensen, Per Torp Sangild

Institut for Idræt og Ernæring

41 Citationer (Scopus)

Abstract

Background & aims: Only few hours of formula feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to formula feeding after some days of total parenteral nutrition (TPN). Methods: After receiving TPN for 2 days, preterm pigs were fed formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated. Results: NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine. Conclusions: Bovine colostrum restores intestinal function after initial formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.

Originalsprog	Engelsk
Tidsskrift	Clinical Nutrition
Vol/bind	33
Udgave nummer	2
Sider (fra-til)	322-329
Antal sider	8
ISSN	0261-5614
DOI	https://doi.org/10.1016/j.clnu.2013.05.013
Status	Udgivet - apr. 2014

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10.1016/j.clnu.2013.05.013

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title = "Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs",

abstract = "Background & aims: Only few hours of formula feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to formula feeding after some days of total parenteral nutrition (TPN). Methods: After receiving TPN for 2 days, preterm pigs were fed formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated. Results: NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine. Conclusions: Bovine colostrum restores intestinal function after initial formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.",

author = "St{\o}y, {Ann Cathrine Findal} and Heegaard, {Peter M. H.} and Thomas Thymann and Mette Bjerre and Kerstin Skovgaard and Mette Boye and Barbara Stoll and Mette Schmidt and Jensen, {Bent B} and Sangild, {Per Torp}",

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T1 - Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs

AU - Støy, Ann Cathrine Findal

AU - Heegaard, Peter M. H.

AU - Thymann, Thomas

AU - Bjerre, Mette

AU - Skovgaard, Kerstin

AU - Boye, Mette

AU - Stoll, Barbara

AU - Schmidt, Mette

AU - Jensen, Bent B

AU - Sangild, Per Torp

N1 - CURIS 2014 NEXS 066

PY - 2014/4

Y1 - 2014/4

N2 - Background & aims: Only few hours of formula feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to formula feeding after some days of total parenteral nutrition (TPN). Methods: After receiving TPN for 2 days, preterm pigs were fed formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated. Results: NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine. Conclusions: Bovine colostrum restores intestinal function after initial formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.

AB - Background & aims: Only few hours of formula feeding may induce proinflammatory responses and predispose to necrotizing enterocolitis (NEC) in preterm pigs. We hypothesized that bovine colostrum, rich in bioactive factors, would improve intestinal function in preterm pigs following an initial exposure to formula feeding after some days of total parenteral nutrition (TPN). Methods: After receiving TPN for 2 days, preterm pigs were fed formula (FORM, n = 14), bovine colostrum (COLOS, n = 6), or formula (6 h) followed by bovine colostrum (FCOLOS, n = 14). Intestinal lesions, function, and structure, abundance and location of bacteria, and inflammation markers were investigated. Results: NEC severity and interleukins (IL)-1β and -8 protein concentrations were lower, while villus height, galactose absorption, and brush-border enzyme activities were increased in the distal small intestine in COLOS and FCOLOS pigs, relative to FORM pigs. Intestinal gene expression of serum amyloid A, IL-1β, -6 and -8, and bacterial abundance, correlated positively with NEC severity of the distal small intestine. Conclusions: Bovine colostrum restores intestinal function after initial formula-induced inflammation in preterm pigs. Further studies are required to test if bovine colostrum may also benefit preterm infants during the challenging transition from total parenteral nutrition to enteral nutrition, when human milk is unavailable.

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DO - 10.1016/j.clnu.2013.05.013

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JO - Clinical Nutrition

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Bovine colostrum improves intestinal function following formula-induced gut inflammation in preterm pigs

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