Benzene-induced genotoxicity in mice in vivo detected by the alkaline comet assay: reduction by CYP2E1 inhibition

Medicin og biovidenskab

• Cytochrome P-450 CYP2E1 95%
• Benzene 92%
• Comet Assay 88%
• Tail 71%
• DNA Damage 64%
• Bone Marrow Cells 27%
• Cytochrome P-450 CYP2E1 Inhibitors 26%
• Lymphocytes 20%
• Propylene Glycol 19%
• Animals 7%

Kemiske forbindelser

• Comet Assay 100%
• Genotoxicity 90%
• Benzene 51%
• Length 43%
• Reduction 33%
• Dose 22%
• Genotoxic 17%
• Glycol 13%
• Propene 12%
• Pharmacological Metabolism 11%
• Metabolite 10%