"Artifactual" arsenate DNA

TY - JOUR

T1 - "Artifactual" arsenate DNA

AU - Nielsen, Peter E

PY - 2012/1

Y1 - 2012/1

N2 - The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual.

AB - The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual.

U2 - 10.4161/adna.19672

DO - 10.4161/adna.19672

M3 - Journal article

C2 - 22679526

SN - 1949-095X

VL - 3

SP - 1

EP - 2

JO - Artificial DNA: PNA and XNA

JF - Artificial DNA: PNA and XNA

IS - 1

ER -