Aquaporin-2 membrane targeting: still a conundrum

Emma Tina Bisgaard Olesen; Robert A. Fenton

doi:10.1152/ajprenal.00010.2017

Aquaporin-2 membrane targeting: still a conundrum

Emma Tina Bisgaard Olesen, Robert A. Fenton

23 Citationer (Scopus)

Abstract

The targeting of the water channel aquaporin-2 (AQP2) to the apical plasma membrane of kidney collecting duct principal cells is regulated mainly by the antidiuretic peptide hormone arginine vasopressin (AVP). This process is of crucial importance for the maintenance of body water homeostasis. In this brief review we assess the role of cyclic adenosine monophosphate (cAMP) and discuss the emerging concept that type 2 AVP receptor (V2R)-mediated AQP2 trafficking is cAMP-independent.

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology: Renal Physiology
Vol/bind	312
Udgave nummer	4
Sider (fra-til)	F744-F747
ISSN	1931-857X
DOI	https://doi.org/10.1152/ajprenal.00010.2017
Status	Udgivet - 7 apr. 2017

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10.1152/ajprenal.00010.2017

https://www.physiology.org/doi/pdf/10.1152/ajprenal.00010.2017

Citationsformater

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Aquaporin-2 membrane targeting: still a conundrum

Abstract

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